This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits blood vessel thickening.
Bosentan blocks a chemical in the blood that causes blood vessels to narrow.
It comes as a tablet to take by mouth, with or without food. Initial: The recommended dose is 62.5 mg twice daily for 4 weeks. Maintenance dose is 125 mg twice daily.
Headache. Lung infection. Flushing. Muscle pain. Swelling. Not able to get a woman pregnant. Anemia may rarely happen. Harm to the liver may rarely happen.
Take a missed dose as soon as you think about it. - If it is close to the time for your next dose, skip the missed dose and go back to your normal time. - Do not take 2 doses at the same time or extra doses. - Do not change the dose or stop this drug. - Talk with the doctor.
If you have an allergy to bosentan or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have liver disease. If you are pregnant or may be pregnant. If you are breast-feeding.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Trouble breathing. Very bad belly pain. Very upset stomach or throwing up. Not able to eat. Dark urine or yellow skin or eyes. Feeling very tired or weak. A big weight gain. For women, if you get pregnant while taking this drug. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category X : Studies in animals or humans have demonstrated fetal abnormalities andor there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Other Cardiovascular Drugs
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