Uses and Benefits

Combiflam ICYHOT Spray 35gm is a non-steroidal anti-inflammatory drug (NSAID) for topical application. This Spray is used in the treatment and prevention of pains such as osteoarthritis, backache, musculoskeletal pains, psoriatic arthritis, and osteochondrosis with the radicular syndrome. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.

Composition

The active ingredients of Combiflam ICYHOT Spray 35gm are Diclofenac 1.16% w/w, Linseed Oil 3% w/w, Menthol 5% w/w, and Methyl Salicylate 10% w/w.

Mechanism of Action of Drugs

Diclofenac acts by inhibiting both leukocyte migration and the enzyme cyclooxygenase (cox-1 and cox-2) leading to the peripheral inhibition of prostaglandin synthesis. Prostaglandins are compounds which basically activate pain receptors. Thus, when Diclofenac inhibits the synthesis of prostaglandins, the analgesic effect of Diclofenac has been produced.
Linseed oil diminishes skin rashes, skin irritation, and redness.
On the other hand, Menthol provides a cooling effect on the skin, post-application.
Lastly, Methyl Salicylate works by giving a temporary analgesic effect.

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before using the Spray:

• Hypersensitivity to any of the components used in the Combiflam ICYHOT Spray 35gm such as Diclofenac, Linseed, Menthol and, Methyl salicylate

• Caution:
• Renal impairment
• Hepatic impairment
• Asthma
• Fluid retention
• GI bleeding

Side and Adverse Effects

The following side effects may or may not occur during the usage of this Combiflam ICYHOT Spray 35gm. It is generally well tolerated when used in the prescribed dosage guidelines. More common ones are generally mild and may include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Rash
• Drowsiness

Rare but more serious adverse effects may include:

• irritability
• Blurred vision
• Anemia
• Exfoliative dermatitis
• Stevens-johnson syndrome

How to Use

Wash your hands as well as the affected area well, before the application. Wipe dry.
Shake the Spray and press gently on the affected area.
Contact with the eyes may cause irritation or burning sensation. Hence, to avoid this, wash your hands well, post-application as well.
Do not spray on the broken, damaged or on open wounds.
Use the spray whenever required (SOS).

Warnings and Precautions

Apply Combiflam ICYHOT Spray 35gm only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Drug Interactions:

Caution always advised when used with other medicines especially when used with other creams, ointments, and Sprays, etc.

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant the use of the drug in pregnant women despite potential risks.