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Deriphyllin M Tablet
Uses and Benefits

Uses and Benefits

Deriphyllin M Tablet is used to treat asthma, acute bronchospasm, and chronic bronchospasm. This tablet helps to relieve one from wheezing, emphysema,chronic asthma, allergic rhinitis, prophylaxis of exercise induced asthma and other respiratory problems. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.



The active ingredients of Deriphyllin M Tablet are Etofylline 231mg, Theophylline 69mg, and Montelukast 10mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Etofylline is used to treat asthma and chronic obstructive pulmonary diseases.

Theophylline is used as a bronchodilator which helps by relaxing the muscles in chest, lungs and reduces the sensitivity in the lungs to allergens and other sources of bronchospasm.

Montelukast is a leukotriene inhibitor. Leukotrienes are the chemicals in our body which are responsible for the allergies, swelling of lungs, tightening of the muscles around airways results in asthma. Therefore, by blocking leukotrines, helps in reducing allergic reactions and asthma.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professional before taking the Deriphyllin M Tablet:

  • Hypersensitivity to any of the ingredients used in the Deriphylline M Tablet such as Etofylline, Theophylline, and Montelukast
  • Caution:
  • PUD active
  • Seizure disorder
  • Arrhythmias
  • Pulmonary edema, acute
  • Cor pulmonale
  • Hepatic impairment
  • Hypothyroidism
  • Febrile
  • Sepsis with multi-organ failure
  • Shock
  • Smoking habit changes
  • Neonates in infants
  • Severe asthma
  • PKU (Phenylalanine-containing forms)
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Deriphyllin M Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Nausea
  • Vomiting
  • Headache
  • Insomnia
  • Diarrhea
  • Irritability
  • Restlessness
  • Tremor
  • Diuresis, transient
  • URI sx
  • Influenza like sx
  • Abdominal pain
  • Otitis media
  • Dyspepsia
  • Rash/urticaria
  • Gastroenteritis
  • Sleep disorders
  • Anxiety irritability
  • Restlessness
  • Tremor

Rare but more serious adverse effects may include:

  • Seizures
  • Arrhythmias
  • Hypotension
  • Shock
  • Exfoliative dermatitis
  • Hypersensitivity reaction
  • Anaphylaxis
  • Skin reaction severe
  • Hepatic eosinophilic infiltration
  • Pulmonary eosinophilia
  • Churg-strauss syndrome
  • Thrombocytopenia
  • Neuropsychiatric disorders
  • Suicidality
  • Aggressive behaviour
  • Hallucinations
  • Depression
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow the Deriphyllin M Tablet whole, immediately after opening the tablet from the strip. Do not break/crush/ chew the tablet.

Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t consume two doses at the same time which is dangerous to your health.

Take the Deriphyllin M Tablet with or without food. May be taken with meals to reduce GI discomfort.
Take the Deriphyllin M Tablet at the prescribed time and dosage.


Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Tachycardia
  • Fever
  • Anorexia
  • Nausea
  • Occasional vomiting
  • Diarrhea
  • Insomnia
  • Irritability
  • Restlessness
  • Agitated maniacal behavior
  • Extreme thirst
  • Tinnitus
  • Palpitations
  • Arrhythmias
  • Delirium
  • Muscle twitching
  • Severe dehydration
  • Albuminuria
  • Emesis of coffee ground material
  • Hyperthermia
  • Profuse Diaphoresis
  • Seizures result in death
Warnings and Precautions

Warnings and Precautions

Take Deriphyllin M Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:


Caution advised among people with hepatic problems. If you have any, consult your doctor before the consumption of this Deriphyllin M Tablet.


Etofylline/Theophylline: Do not take the medicine if you are pregnant or likely to get pregnant because safety during pregnancy is unknown. However, consider taking the tablet if suggested by a healthcare professional.
Montelukast: May be used during pregnancy – risk of infant harm not expected based on limited human data.


Etofylline/Theophylline: Inform your doctor if you are a nursing mother because safety during lactation is not yet established.
Montelukast: May be used during lactation – risk of infant harm not expected based on limited human data and drug properties.


Increased renal clearance with alcohol.


Decreased absorption of drug with food. Serum levels may be decreased with st. John?s wort.

Drug Interactions:

Caution always advised when used with other medication. Therefore, inform your doctor about your current list of medication which you start or stop.

  • Keep the Deriphyllin M Tablet out of sight and reach of children.
  • Store at 20-250 C away from heat and moisture.
  • Do not use Deriphyllin M Tablet beyond its expiry.
  • Do not accept the torn strip or a broken tablet.
FDA Pregnancy Category

FDA Pregnancy Category

Category N: No information available.

Drug Composition information
What is Montelukast for:

This medication is a leukotriene receptor antagonists (LTRAs), prescribed for asthma. It works by blocking a substance called leukotriene.

How does Montelukast work:

Montelukast lowers the bodys making of a group of chemicals called leukotrienes that cause asthma to get worse. - It lowers or stops the bodys reaction to the allergen.

How should Montelukast be used:

It comes as a tablet to take by mouth with or without food. The recommended dose is 10 mgday.

Common side effects of Montelukast :

Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating. Mild pain drugs may help. Nervous and excitable. Headache. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Nose stuffiness.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Montelukast :

If you have an allergy to montelukast or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life. Trouble breathing. Cough that does not go away. Use of short-acting puffer (inhaler) more often. Numbness or tingling in your hands or feet. Dark urine or yellow skin or eyes. Not able to eat. Change in the way you act. Any skin change. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Montelukast with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Montelukast :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Antiasthmatic & COPD Preparations

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