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DOLOWIN-MR TAB

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MRP 82

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10 Units/pack

DOLOWIN-MR TAB
Dolowin MR Tablet
Uses and Benefits

Uses and Benefits

Dolowin MR Tablet is a non-steroidal anti-inflammatory drug and analgesic agent generally prescribed for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It relieves one from inflammation and pain. This tablet is also used as a muscle relaxant. In addition, it produces a sedative effect. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.

Composition

Composition

The active ingredients of Dolowin MR Tablet are Aceclofenac 100mg, Paracetamol (also known as Acetaminophen) 325mg and Chlorzoxazone 250mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Aceclofenac is a derivative of phenylacetic acid that withholds the participation of Cyclooxygenase compound. Cyclooxygenase is an enzyme that is responsible for the formation of prostanoids including thromboxane and prostaglandins. Prostaglandins are responsible for causing the pain, fever, swelling, and redness. Thus with the entire process, pain causing factors are eliminated.

Paracetamol or Acetaminophen primarily acts as an analgesic and an antipyretic agent. It also possesses anti-inflammatory properties. It produces its analgesic effects by increasing the pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.

Lastly, Chlorzoxazone reduces skeletal muscle spasm and relieves one from pain.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before taking the Dolowin MR Tablet:

  • Hypersensitivity to any of the components used in the Dolowin MR Tablet such as Aceclofenac Paracetamol (Acetamnophen), and Chlorzoxazone
  • Hepatic impairment severe
  • Caution:
  • Hepatic impairment ( mild to moderate)
  • Hypovolemia
  • Malnutrition, chronic
  • In elder patients
  • Renal impairment
  • CNS depression
  • CNS depression use
  • Alcohol use
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Dolowin MR Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Diarrhea
  • Nausea
  • Redness on skin
  • Vomiting
  • Running nose
  • Headache
  • Insomnia
  • Stomach cramps
  • Drowsiness
  • Dizziness
  • Lightheadedness
  • CNS stimulation
  • Malaise
  • Dyspepsia
  • Urine discoloration

Rare but more serious adverse effects may include:

  • Blood dyscrasias
  • Liver damage
  • Severe GI bleeding
  • Nephrotoxicity
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow the tablet whole, immediately after opening the tablet from the strip. Do not break/chew/crush the tablet.

Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.

Take the Dolowin MR Tablet with or without food, preferably after food to avoid GI discomfort.

For adults, the usual dosage is 1 tablet in the morning and 1 tablet in the evening or as directed by your physician or a pharmacist.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Rashes on the skin
  • Confusion
  • Chest pain
  • Blurred vision
Warnings and Precautions

Warnings and Precautions

Take Dolowin MR Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Caution advised among people with renal problems. If you have any, it is highly recommended that you consult your doctor before the consumption of Dolowin MR Tablet.

Liver:

Caution advised among people with hepatic problems. If you have any, it is highly recommended that you consult your doctor before the consumption of this medicine.

Pregnancy:

Do not take Dolowin MR Tablet if you are pregnant or planning to become pregnant because the safety of consuming this medicine during pregnancy is not yet established.

Lactation:

Inform your doctor if you are a nursing mother because safety of consuming this medicine during lactation is not established. However, consider taking medicine only if it suggested by your doctor.

Alcohol:

Do not take Dolowin MR Tablet along with alcohol as this may increase your hepatic problems.

Driving:

Since consuming this medicine would induce sleep/cause dizziness, do not drive, operate heavy machinery or involve in any works which may demand your attention/physical strength.

Drug Interactions:

Aceclofenac: Increased nephrotoxicity with diuretics.
May enhance the activity of anticoagulants.
May increase plasma methotrexate levels leading to toxicity if administered within 2-4 hr of methotrexate administration.
Paracetamol or acetaminophen: This may reduces the absorption of cholestyramine within 1 hour of administration.
Chlorzoxazone: Increased CNS effect with other CNS depressants.
Increased serum Concentration with Disulfiram and Isoniazid.

Precautions
  • Keep the medicine out of reach of children.
  • Store in a room temperature, protected from heat and moisture.
  • Do not use the medicine beyond its expiry.
  • Do not accept torn strip or broken tablet.
FDA Pregnancy Category

FDA Pregnancy Category

Category N: No information available.


Drug Composition information
What is Aceclofenac for:

It is prescribed for fever, pain and arthritis

How does Aceclofenac work:

It is a nonsteroidal anti-inflammatory drug (NSAID), that blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain and swelling

How should Aceclofenac be used:

To gain the most benefit, take the medicine daily or as prescribed by your doctor. It is usually taken twice a day. Take it with food.

Common side effects of Aceclofenac :

Indigestion, heartburn, dyspepsia, diarrhoea, nausea, abdominal pain and flatulence.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Many times this drug is taken on an as needed basis.

What precautions should I take when taking Aceclofenac :

Inform your doctor is you suffer from history of peptic ulceration, cerebrovascular bleeding, ulcerative colitis, crohns disease, systemic lupus erythmatosus, porphyria, haematopoietic or coagulation disorders. The dose will be adjusted in people with hepatic, renal or cardiac function impairment.

When do I need to seek medical help

Do not take the drug if you had an allergic reaction to the medication in the past. Stop taking this drug and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; rash; wheezing; itching; closing of your throat; swelling of your lips, tongue, or face; or hives).

Can I take Aceclofenac with other medicines:

Inform you doctor is you are taking lithium, digoxin, diuretics or ACE inhibitors. Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Aceclofenac :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category N : Not yet classified.

Therapeutic Classification

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Non-Opioid Analgesics & Antipyretics

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