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DOMSTAL RD CAP
Domstal RD Capsule
Uses and Benefits

Uses and Benefits

Domstal RD Capsule is used in the treatment of peptic ulcer, NSAID associated ulceration, H. pylori infection, gastroesophageal reflux disease, zollinger ellison syndrome, heartburn, and acid-related dyspepsia. Besides, it is also used to prevent nausea and vomiting. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.

Composition

Composition

The active ingredients of Domstal RD Capsule are Omeprazole 20mg and Domperidone 10mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Omeprazole is a proton pump inhibitor. Proton pumps are present on the cells of the stomach lining that help to produce stomach acid. Therefore, as an inhibitor, when omeprazole targets proton pumps, lesser stomach acid is produced thus reducing refluxes.

Domperidone possesses anti-emetic properties which help reduce vomiting and vomiting sensation; and also treats gastric problems to an extent.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professional before taking Domstal RD Capsule:

  • Hypersensitivity to any of the Components used in the Domstal RD Capsule such as Omeprazole and Domperidone
  • GI bleeding
  • Influenza
  • Flu-like symptoms or chickenpox
  • Advanced chronic renal impairment
  • Caution:
  • Long term use
  • Hepatic impairment
  • Hypomagnesemia
  • Elderly patients (high dose or long term use)
  • History of GI bleeding or ulcer
  • Cardiovascular disease
  • HTN
  • CHF
  • Fluid retention
  • Dehydration
  • Renal impairment
  • Hepatic impairment
  • Elderly or debilitated patients
  • Coagulation disorder
  • Anticoagulant use
  • Corticosteroid use
  • Concurrent diuretics
  • Alcohol use
  • Smoker
  • Asthma
  • Long term use
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Domstal RD Capsule. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Flatulence
  • Vitamin B 12 deficiency
  • Fundic gland polyps (long term use)
  • Tinnitus
  • Dyspepsia
  • Indigestion
  • Constipation

Rare but more serious adverse effects may include:

  • Hypersensitivity reaction
  • Anaphylaxis
  • Steven-johnson syndrome
  • Toxic epidermal necrolysis
  • Erythema multiforme
  • Renal impairment
  • Fractures
  • Pancreatitis
  • Blood dyscrasias
  • Hepatic impairment
  • Clostridium difficile associated diarrhea
  • Lupus erythematosus
  • Interstitial nephritis
  • MI
  • Hearing loss
  • Hepatitis
  • Reye syndrome
  • Renal papillary necrosis
  • GI bleeding
  • GI perforation/ulcer
  • Bronchospasm
  • Prolonged bleeding time
How to Use

How to Use

Do not exceed the dose prescribed by your doctor.
Swallow the tablet whole immediately after opening it from the strip. Do not break/chew/cut the tablet.
Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t consume two doses at the same time which may be dangerous to your health.
Domstal RD Capsule may be taken either with or without food – preferably without food or 15-30 min before food.
Take the dosage at the prescribed time and quantity.
For children, talk to your doctor before giving the tablet.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Confusion
  • Depression
  • Apathy
  • Vomiting
  • Nausea
  • Headache
  • Dizziness
  • Abdominal pain
  • Diarrhea
  • Altered consciousness
  • Convulsion
  • Agitation
  • Somnolence
  • Extrapyramidal reactions
  • Disorientation
Warnings and Precautions

Warnings and Precautions

Take Domstal RD Capsule only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Caution advised among people with renal problems. If you have any, it is highly recommended that you consult your doctor before the consumption of this Domstal RD Capsule.

Liver:

Caution advised among people with hepatic problems. If you have any, it is highly recommended that you consult your doctor before the consumption of this medicine.

Pregnancy:

Caution advised during pregnancy; a risk of teratogenicity expected based on insufficient human data. Therefore, inform your doctor if you are pregnant or planing to become pregnant (inform before consumption of this medicine).

Lactation:

Omeprazole: May be used during lactation; no human data available to evaluate effects on milk production but risk to the breastfeeding infant is not expected based on the drug properties and less quantity of drug excretion into milk.

Domperidone: Do not take this medicine if you are a nursing mother, consider taking the medicine only if suggested by your doctor.

Drug Interactions:

Caution always advised when used with other drugs such as Diuretics, Warfarin, Digoxin, Benzodiazepines, Clarithromycin, and Methotrexate, Dichlorphenamide, Live vaccine for Influenza nasal, varicella live vaccine.
Decreased absorption of itraconazole, Posaconazole, Dasatinib, and Ketoconazole, etc.Therefore, inform your doctor if your start or stop using any medication during the treatment (if any).

Precautions
  • Keep the medicine out of sight and reach of children.
  • Store in room temperature, away from heat and moisture.
  • Do not use Domstal RD Capsule beyond its expiry.
FDA Pregnancy Category

FDA Pregnancy Category

Category N: No information available.


Drug Composition information
What is Domperidone for:

This medication is an antidopaminergic agent, used in treating nausea, vomiting, gastrointestinal problems and Parkinson?s disease.

How does Domperidone work:

Domperidone helps the stomach get rid of food and lowers signs of an upset stomach, throwing up, heartburn, and fullness.

How should Domperidone be used:

Adult: Oral- Nausea and vomiting- 10-20 mg 4-8 hourly. Max: 80 mgday. Non ulcer dyspepsia- 10-20 mg 3 timesday and at night. Migraine- 20 mg 4 hourly. Max: 4 doses24 hour. Rectal- Nausea and vomiting- 60 mg twice daily. It is available in various forms like tablet, drop, suspension, capsule to take by mouth, on an empty stomach.

Common side effects of Domperidone :

Headache. Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Domperidone :

Alert your doctor if you have stomach problems (such as stomach bleeding or intestinal blockage) or prolactinoma (a tumour that releases a hormone called prolactin). - Alert your doctor if you have heart, liver or kidney disease, or if you have breast cancer. - Alert your doctor if you are pregnant or breastfeeding. Do not breastfeed while being treated with Domperidone.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. A fast heartbeat. Very bad dizziness or passing out. Seizures. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Domperidone with other medicines:

Alert your doctor quickly if you are taking any of the following medications: - bromocriptine - heart medicines, especially those used to control irregular heartbeat. - antidepressants known as MAOI, such as phenelzine, isocarboxazid. - other mood medicines such as mesoridazine, thioridazine. - painkillers such as codeine, morphine. - Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

Are there any food restrictions

Avoid Alcohol

How do I store Domperidone :

Oral: Store it at controlled room temperature (15-30C).

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Antiemetics, GIT Regulators & Anti-Inflammatories

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