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DYNAPAR 100MG SUPP

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Dynapar Suppository 100mg
Uses and Benefits

Uses and Benefits

Dynapar Suppository 100mg is designed to be inserted into the rectum to dissolve. This medicine is a non steroidal anti-inflammatory drug (NSAID) with anti pyretic and analgesic actions used in the treatment of acute and chronic signs and symptoms of osteoarthritis and rheumatoid arthritis. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.

Composition

Composition

The active ingredient of Dynapar Suppository 100mg is Diclofenac 100mg.

Mechanism of Action of Drugs

Mechanism of Action of Diclofenac

Diclofenac acts by inhibiting both leukocyte migration and the enzyme cyclooxygenase (cox-1 and cox-2) leading to the peripheral inhibition of prostaglandin synthesis. Prostaglandins are the compounds which basically activate pain receptors. Thus, when Diclofenac inhibits the synthesis of prostaglandins, the analgesic effect of Diclofenac has been produced.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before using Dynapar Suppository 100mg:

  • Hypersensitivity to any of the ingredient used in the Suppository such as Diclofenac
  • ASA or NSAID induced asthma or urticaria
  • Aspirin traid
  • CABG surgery periop use
  • Caution:
  • Renal impairment
  • Hepatic impairment
  • Asthma
  • Cardiovascular disease
  • Cardiac disease risk
  • HTN
  • CHF
  • Fluid retention
  • Coagulation disorder
  • GI Bleeding orulcer
  • Prolonged use
  • Smoker
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Dynapar Suppository 100mg. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Dyspepsia
  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Constipation
  • Flatulence
  • Headache
  • Dizziness
  • Rash
  • Pruritus
  • Urticaria
  • Drowsiness
  • Fluid retention
  • Peripheral edema
  • Tinnitus
  • Sinusitis
  • Photosensitivity
  • Delayed Ovulation

Rare but more serious adverse effects may include:

  • GI Bleeding
  • GI perforation
  • Ulcer
  • Stroke
  • Thromboembolism
  • HTN
  • CHF
  • Renal papillary necrosis
  • Nephrotoxicity
  • Hepatotoxicity
  • Pancreatitis
  • Anaphylactoid reaction
  • Bronchospasm
  • Exfoliative dermatitis
  • Steven-Johnson syndrome
  • Erythema multiforme
  • Anemia
  • Blood dyscrasias
  • Prolonged bleeding time
  • Hyperkalemia
How to Use

How to Use

Do not exceed the dose prescribed by your doctor.
Wash your hands before and after the application of Dynapar suppository 100mg.
To begin, lie down on your back, insert the suppository carefully into the rectum.
Push as deep as possible, ensure the suppository has deposited into the rectum.

Try not to skip the dose; if you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Do no take two doses at the same time which is dangerous to your health and may lead to severe adverse effects.

Dosage as recommended by your doctor.

Overdosage

Avoid using more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Lethargy
  • Tinnitus
  • Headache
  • Drowsiness
  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Disorientation
  • Excitation
  • Epigastric pain
  • Anaphylactoid reactions
  • Fits
  • Coma
  • Acute renal failure
Warnings and Precautions

Warnings and Precautions

Take the Suppository only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Caution advised among people with renal problems. If you have any, consult your doctor before the consumption of this medicine.

Liver:

Caution advised among people with hepatic problems. If you have any, consult your doctor before the consumption of this medicine.

Pregnancy:

Caution advised in the 1st trimester as well as the last trimester – better to avoid using this medicine during these periods. Human data suggests a risk of embryo-fetal harm.

Lactation:

May be used during pregnancy – no known risk of infant harm based on drug properties and limited human data. However, there is no human data available to evaluate effects on milk production.

Drug Interactions:

Caution always advised when used along with other medicines especially inform your doctor if you start or stop using medicines such as Cyclosporin, Lithium, Methotrexate, Rifampin, Antifungal medicines, Blood thinners, Heart or blood pressure medicines, NSAIDs, steroids and any other forms of Diclofenac.

Precautions
  • Keep Dynapar Suppository 100mg out of sight and reach of children.
  • Store between 20-25oC away from heat and moisture.
  • Do not use the medicine beyond its expiry.
  • Do not use Dynapar Suppository 100mg if the package is torn before its use.
FDA Pregnancy Category

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Drug Composition information
What is Diclofenac for:

This medication is an NSAID, prescribed for severe pain. This medication decreases the hormones that cause inflammation and pain in the body.

How does Diclofenac work:

Diclofenac blocks chemicals that cause pain and swelling.

How should Diclofenac be used:

PO- The recommended dosage is 100-200 mgday in divided doses.Topical- Apply the gel (4 g) to the affected area, 4 times daily. It comes as a tablet to take by mouth, with food.It also comes as a gel to apply topically.

Common side effects of Diclofenac :

Headache. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative. Loose stools (diarrhea). Harm to the liver may rarely happen.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Many times this drug is taken on an as needed basis

What precautions should I take when taking Diclofenac :

If you have an allergy to diclofenac or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are more than 24 weeks pregnant.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Chest pain or pressure. Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight. Very upset stomach or throwing up. Very bad belly pain. Very bad swelling or pain of hands or feet. A big weight gain. Black, tarry, or bloody stools. Blood in the urine. Very loose stools (diarrhea). Not able to eat. Any bruising or bleeding. Yellow skin or eyes. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Diclofenac with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Diclofenac :

Store it at room temperature and in an airtight container. Keep away from excess heat and moisture.

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) , Non-Opioid Analgesics & Antipyretics

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