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DYNAPAR TAB
Dynapar Tablet
Uses and Benefits

Uses and Benefits

Dynapar tablet is most commonly used in the treatment of mild to moderate pains such as muscle aches, headache, toothache, arthritis, backache, menstrual cramps, sprains, strains, and fever, and post-immunization pyrexia. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.

Composition

Composition

The active ingredients of Dynapar tablet are Diclofenac 50mg and Paracetamol 325mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Diclofenac acts by inhibiting both leukocyte migration and the enzyme cyclooxygenase (cox-1 and cox-2) leading to the peripheral inhibition of prostaglandin synthesis. Prostaglandins are the compounds which basically activate pain receptors. Thus, when Diclofenac inhibits the synthesis of prostaglandins, the analgesic effect of Diclofenac has been produced.

Paracetamol (also known as. Acetaminophen) primarily acts as an analgesic and antipyretic agent. Further, it also has anti-inflammatory properties to a certain extent. The Paracetamol produces an analgesic effect by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before taking Dynapar tablet:

  • Hypersensitivity to any of the ingredients used in the Dynapar tablet such as Diclofenac and
  • Paracetamol
  • Hepatic impairment
  • Malnutrition
  • Hypovolemia
  • Chronic alcohol use
  • Caution:
  • Renal impairment
  • Hepatic impairment
  • Asthma
  • Fluid retention
  • GI bleeding
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Dynapar tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Nausea
  • Skin rash
  • Tinnitus
  • Dryness of mouth
  • Decreased appetite
  • Mouth ulcer
  • Gastric problems
  • Palpitation
  • Dizziness
  • Abdominal discomfort

Rare but more serious adverse effects may include:

  • Thrombocytopenia
  • Hypokalemia
  • Anemia
  • Hepatotoxicity
  • Anaphylaxis
  • Renal tubular necrosis, acute
  • Blurred vision
  • Exfoliative dermatitis
  • Stevens-Johnson Syndrome
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow the Dynapar tablet whole, immediately after opening the tablet from the strip. Do not break/cut/chew the tablet.
Avoid missing a dose. If you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Do not swallow two doses at the same time which is dangerous to your health.
Take the Dynapar tablet with or without food.
For adults; Do not exceed more than 3 doses in a day or take it as directed by your physician or pharmacist.
For children; talk to your doctor before giving the tablet.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience any one or more of the following signs or symptoms:

  • Abdominal pain
  • Yellow skin
  • Blood clotting
  • Confusion
  • Hypoglycemia
  • Lactic acidosis
  • Lethargy
  • Drowsiness
  • Nausea
  • Vomiting
  • Tinnitus
  • Disorientation
  • Epigastric pain
  • Respiratory depression
  • Acute renal failure
  • Coma
Warnings and Precautions

Warnings and Precautions

Take Dynapar tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Inform your doctor if you have any renal problems, before taking the Dynapar tablet.

Liver:

Talk to your doctor if you have any hepatic problems, before taking the Dynapar tablet.

Pregnancy:

Diclofenac: Caution advised in the 1st trimester as well as the last trimester – better to avoid using this medicine during these periods. Human data suggests a risk of embryo-fetal harm.
Paracetamol (Acetaminophen): It may be used during pregnancy – no known risk of fetal harm.

Lactation:

Diclofenac: May be used during pregnancy – no known risk of infant harm based on drug properties and limited human data. However, there is no human data available to evaluate effects on milk production.
Paracetamol (Acetaminophen): This medicine may be used while breastfeeding – no known risk of infant harm based on human data. However, no human studies are available to estimate effects on milk production.

Alcohol:

This may or may not induce sleep – depends upon individual capability. Therefore, if you experience drowsiness, do not drive, operate heavy machinery, or involve in any other works which needs your alertness.

Driving:

This may or may not induce sleep – depends upon individual capability. Therefore, if you experience drowsiness, do not drive, operate heavy machinery, or involve in any other works which needs your alertness.

Drug Interactions:

Affected by delayed gastric emptying, analgesic-associated nephropathy and methemoglobinemia.

Precautions
  • Keep the medicine out of sight and reach of children.
  • Keep it in a hygienic and cool place away from heat and moisture.
  • Do not use the medicine beyond its expiry.
  • Do not use Dynapar tablet if the tablet strip is torn or the tablet is broken.
FDA Pregnancy Category

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Drug Composition information
What is Diclofenac for:

This medication is an NSAID, prescribed for severe pain. This medication decreases the hormones that cause inflammation and pain in the body.

How does Diclofenac work:

Diclofenac blocks chemicals that cause pain and swelling.

How should Diclofenac be used:

PO- The recommended dosage is 100-200 mgday in divided doses.Topical- Apply the gel (4 g) to the affected area, 4 times daily. It comes as a tablet to take by mouth, with food.It also comes as a gel to apply topically.

Common side effects of Diclofenac :

Headache. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative. Loose stools (diarrhea). Harm to the liver may rarely happen.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Many times this drug is taken on an as needed basis

What precautions should I take when taking Diclofenac :

If you have an allergy to diclofenac or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are more than 24 weeks pregnant.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Chest pain or pressure. Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight. Very upset stomach or throwing up. Very bad belly pain. Very bad swelling or pain of hands or feet. A big weight gain. Black, tarry, or bloody stools. Blood in the urine. Very loose stools (diarrhea). Not able to eat. Any bruising or bleeding. Yellow skin or eyes. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Diclofenac with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Diclofenac :

Store it at room temperature and in an airtight container. Keep away from excess heat and moisture.

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) , Non-Opioid Analgesics & Antipyretics

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