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Febrex Plus Tablet
Uses and Benefits

Uses and Benefits

Febrex Plus tablet is usually prescribed to treat common cold and fever, reduce ear pain, allergy, headache, hay fever, running nose, flu, joint pain, itchy throat or skin, and toothache, etc. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.



The active ingredients of Febrex Plus tablet are Phenylephrine 10mg, Paracetamol (also known as Acetaminophen) 500mg, Chlorpheniramine Maleate 2mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Phenylephrine acts on alpha-adrenergic receptors, thus helps to reduce nasal congestion, allergies, fever and reduces swollen blood vessels in the nasal passage, if any.

Paracetamol (or Acetaminophen) primarily acts as an analgesic and an antipyretic agent. It also possesses anti-inflammatory properties. It produces its analgesic effects by increasing the pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.

Chlorpheniramine Maleate basically tames allergy symptoms by attaching to histamine receptors. Histamines are responsible for allergic and inflammatory reactions. Chlorpheniramine Maleate blocks the action of the endogenous histamine, by reducing the negative symptoms brought on by histamine.

Contraindications and Conditions

Contraindications and Conditions

Patients with the following conditions are suggested to seek advice from their health care professionals before taking the tablet:

  • Hypersensitivity to any of the drugs used in Febrex Plus tablet (Phenylephrine, Paracetamol, and Chlorpheniramine Maleate)
  • Urinary retention
  • Caution:
  • Asthma
  • Arrhythmias
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of this tablet. It is generally well tolerated when taken in prescribed dosage guidelines. Common ones are generally mild and may include:

  • Nausea
  • Skin rash
  • Skin reddening
  • Allergic reactions
  • Shortness of breath
  • Feeling of sickness
  • Tinnitus
  • Dryness of mouth
  • Decreased appetite
  • Anemia
  • Mouth ulcer
  • Gastric problems
  • Palpitation
  • Dizziness
  • Abdominal discomfort

Rare but more serious adverse effects may include:

  • Anxiety
  • Reflex bradycardi
  • Tachycardia
  • Arrhythmia
  • Gangrene
  • Hypertension
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow the tablet whole. Do not break or chew. Take it immediately after opening the tablet from the strip.
Avoid missing a dose. In case you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.
Take Febrex Plus tablet with food.
For adults, the usual dosage is 1 tablet 3-4 times a day or as suggested by your physician or health care professional.
For children talk to your doctor before giving the tablet.


Avoid taking more than the prescribed dosage. In case of an accidental over dose, seek prompt medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Vomiting
  • Hypertension
  • Palpitation
  • Paresthesia
  • Ventricular extrasystoles
Warnings and Precautions

Warnings and Precautions

Take the tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Pregnancy: Paracetamol or Acetaminophen: May be used during pregnancy, no known risk of fetal harm.
Chlorpheniramine: May be used during pregnancy, risk of fetal harm is low based on human data.
Phenylephrine: Avoid use in the 1st trimester, caution advised in 2nd and 3rd trimesters.

Lactation: Though there has been no record of harm being caused to the infant due to the consumption of Febrex Plus tablet, it is best to consult the doctor before the consumption of this tablet to be on the safer side.

Alcohol: Consumption of alcohol along with Febrex Plus tablet may lead to hepatic damage, thus avoid mixing both.

Driving: Taking Febrex Plus tablet may induce sleep. So do not drive, operate any machinery or involve in works which may need your attention/physical strength.

Drug Interactions: Affected by delayed gastric emptying.

  • Keep Febrex Plus tablet out of sight and reach of children.
  • Store in a cool and dry place, away from sunlight and moisture.
  • Do not use Febrex Plus tablet beyond its expiry.
FDA Pregnancy Category

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant the use of the drug in pregnant women despite potential risks.

Drug Composition information
What is acetaminophen for:

It is used to used to relieve mild to moderate pain and to reduce fever.

How does acetaminophen work:

Acetaminophen blocks chemicals that cause pain. It lowers fever by changing the bodys thermostat in the brain.

How should acetaminophen be used:

Take this as directed by your doctor. Do not take more than instructed by your doctor. Never take more than 1000 mg at any one time and no more than 4 times in one day. The dose for a child is different from the adult dose. Be sure to check with your doctor or pharmacist before giving this medicine to a child. It may be taken with or without food. If you need pain relief fast, take it on an empty stomach as food may slow down the absorption. You may stop taking it when you have no more pain or fever. Take it only when you need to.

Common side effects of acetaminophen :

Upset stomach or throwing up. Harm to the liver may rarely happen.

What do I do if I miss a dose

Many times this drug is taken on an as needed basis.

What precautions should I take when taking acetaminophen :

Do not take this drug if you had an allergy to this or similar drugs in the past. Do not take it if you have liver or kidney failure.

When do I need to seek medical help

Seek help if you are having an allergic reaction to the drug. Signs include rash, difficulty breathing, swelling of the lips, face, tongue; or hives. Symptoms of an overdose may include nausea; vomiting; loss of appetite; sweating; extreme tiredness; unusual bleeding or bruising; pain in the stomach; yellowing of the skin. Contact an emergency centre immediately if you suspect overdose.

Can I take acetaminophen with other medicines:

Alert your doctor if you are taking blood-thinning medicines such as warfarin.

Are there any food restrictions

Avoid Alcohol

How do I store acetaminophen :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) , Non-Opioid Analgesics & Antipyretics

Seller Information
Manufactured By


at 86-a, l.b.s. marg mulund (w)mumbai 400080

Packed By


at 86-a, l.b.s. marg mulund (w)mumbai 400080

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