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MEFTAL SPAS TAB
Meftal Spas Tablet
Uses and Benefits

Uses and Benefits

Meftal Spas Tablet is a non-steroidal, anti-inflammatory drug (NSAID) used in the treatment of fever, heavy menstrual bleeding, menstrual pain, muscle cramps, headache, muscle pain, stomach pain, abdomen pain, and joint pain. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor?s discretion.

Composition

Composition

The active ingredients of Meftal Spas tablet are Mefenamic Acid 250mg and Dicyclomine (or Dicycloverine) 10mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Mefenamic Acid acts by restraining cyclooxygenase, an enzyme responsible for the formation of prostanoids. Prostanoids consist of prostaglandins and prostaglandins are responsible for inflammation and anaphylactic reactions. Thus reducing inflammation and pain.

On the other hand, Dicyclomine (or Dicycloverine) is an anticholinergic drug that reduces muscle spasms in the gastrointestinal tract through a process of nonselective smooth muscle relaxation. An anticholinergic agent is basically a substance which blocks the neurotransmitter acetylcholine in both central and peripheral nervous systems. It inhibits the parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.

Contraindications and Conditions

Contraindications and Cautions

Patients with the following conditions are suggested to seek advice from their health care professional before taking the medicine:

  • Hypersensitivity to any of the drugs used in the tablet such as Mefenamic Acid and
  • Dicyclomine (or Dicycloverine).
  • ASA or NSAID induced asthma or urticaria
  • CABG surgery perioperative use
  • Severe ulcerative colitis
  • Obstructive uropathy
  • Glaucoma
  • Caution:
  • Renal impairment
  • Hepatic impairment
  • Coagulation disorder
  • Cardiovascular disease
  • Asthma
  • GI bleeding or ulcer
  • Psychosis
  • Hiatal hernia
  • Prostat hypertrophy
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of this Meftal Spas tablet. It is generally well tolerated when taken in prescribed dosage guidelines. More common ones are generally mild and may include:

  • Nausea
  • Constipation
  • Headache
  • Dizziness
  • Tinnitus
  • Fluid retention
  • Photosensitivity
  • Rash
  • Delayed ovulation
  • Abdominal pain
  • Asthenia
  • Palpitation

Rare but more serious adverse effects may include:

  • GI bleeding
  • Stroke
  • Hepatotoxicity
  • Nephrotoxicity
  • Bronchospasm
  • Renal papillary necrosis
  • Exfoliative dermatitis
  • Psychosis?Delirium
  • Paralytic ileus
How to Use

Do not exceed the dose prescribed by your doctor.
Swallow the tablet whole, immediately after opening the tablet from the strip. Do not break or chew the tablet.
Avoid missing/forgetting a dose. If you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Don’t consume two doses at the same time which is dangerous to your health.
Take Meftal Spas tablet with food or after food.
For adults, the usual dosage is 1 tablet 2-3 times in a day or as suggested by your physician, pharmacist or health care professional.
For children talk to your doctor before giving the tablet.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental over dose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Headache
  • Nausea
  • Vomiting
  • Epigastric pain
  • GI bleeding
  • Coma
  • Drowsiness
  • Fainting
  • Disorientation
  • Excitation
  • Difficulty in swallowing
  • Hot dry skin
Warnings and Precautions

Warnings and Precautions

Take Meftal Spas tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Liver: Tell your doctor if you have any liver disease or disorders – he/she will suggest whether to take the Meftal Spas tablet or not.

Pregnancy:

Mefenamic Acid: Tell your doctor if you are pregnant or plan to become pregnant. Caution advised in the 1st trimester and avoid taking this tablet during the last 3
months of pregnancy.
Dicyclomine: Based on human data, no known risk of the fetus – may be used during pregnancy.

Lactation:

Mefenamic Acid: Avoid breastfeeding while using Meftal Spas tablet, because the drug can pass through breast milk and harm a nursing baby.
Dicyclomine: Do not breast-feed while using this medicine. There is a possible risk of infant apnea based on limited human data. And, there are no human studies available to estimate the effects on milk production.

Alcohol: Consumption of alcohol may increase your risk of stomach bleeding along with Meftal Spas tablet.

Driving: Do not drive or operate heavy machinery or involve in any other works which may need mental alertness/physical strength.

Precautions
  • Keep Meftal Spas tablet out of sight and reach of children.
  • Store at room temperature, away from moisture and heat.
  • Do not use the medicine beyond its expiry date.
  • Do not use the medicine if the tablet strip is torn or the tablet is discolored.
FDA Pregnancy Category

FDA Pregnancy Category

Category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant the use of the drug in pregnant women despite potential risks.


Drug Composition information
What is Dicyclomine for:

This medication is an anticholinergic, prescribed for irritable bowel syndrome. It blocks a chemical in the smooth muscle of the stomach and intestines.

How does Dicyclomine work:

Dicyclomine slows movement in the GI (gastrointestinal) tract, lowering the number of spasms.

How should Dicyclomine be used:

Adult: PO- 10-20 mg 3 timesday. IM- 20 mg 4 timesday for 1-2 days. Replace with oral therapy as soon as possible. It comes as a tablet to take by mouth with or without food.

Common side effects of Dicyclomine :

Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative. - Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses.

What precautions should I take when taking Dicyclomine :

Do not give this drug to an infant younger than 6 months of age. If you have an allergy to dicyclomine or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of these health problems: Enlarged prostate, glaucoma, bowel block, myasthenia gravis, or trouble passing urine. If you are breast-feeding.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad dizziness or passing out. Change in thinking clearly and with logic. Not able to pass urine. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Dicyclomine with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Dicyclomine :

Store it at room temperature. Keep this medication in the container it came in and out of the reach of children. Protect it from light and heat.

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Antispasmodics , GIT Regulators & Anti-Inflammatories

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