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MEGA FLEXON TAB
Mega Flexon Tablet
Uses and Benefits

Uses and Benefits

Mega Flexon Tablet is most commonly prescribed to treat fever, mild to moderate pains such as muscle aches, headache, toothache, arthritis, backache, menstrual cramps, and post-immunization pyrexia. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.

Composition

Composition

The active ingredients of Mega Flexon Tablet are Paracetamol (also known as Acetaminophen) 325mg and Tramadol 37.5mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Paracetamol (or Acetaminophen) primarily acts as an analgesic and an antipyretic agent. It also possesses anti-inflammatory properties. It produces its analgesic effects by increasing the pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.

Tramadol acts by withholding the chemical neurotransmitters which enhance pain. Simultaneously, this drug also enhances the serotonin release which contributes to happiness and well-being by calming and relaxing the mind.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before taking the Mega Flexon Tablet:

  • Hypersensitivity to any of the components used in the Mega
  • Flexon Tablet such as Paracetamol (also known as
  • Acetaminophen) and Tramadol
  • Hypersensitivity to opioids
  • MAO inhibitor use within 14 days
  • Respiratory depression risk (12-18 years old)
  • Post-tonsillectomy or adenoidectomy use (< 18 years old)
  • Respiratory depression, severe
  • Asthma, acute or severe
  • GI obstruction, known or suspected
  • Paralytic ileus
  • Acute alcohol or drug intoxication
  • Suicidal ideation or behavior
  • Circulatory shock
  • Coma or impaired consciousness
  • Electrolyte abnormalities
  • Hepatic impairment (severe)
  • Renal impairment (severe)
  • Caution:
  • Hepatic impairment
  • Malnutrition
  • Hypovolemia
  • Chronic alcohol use
  • Pulmonary impairment
  • Head injury
  • Sleep apnea
  • Concurrent CNS depressant use
  • Alcohol use
  • History of mental illness
  • Psychiatric disorder
  • Hypovolemia
  • Acute pancreatitis or biliary disease
  • Congenital long QT syndrome
  • QT prolongation
  • QT prolongation family history
  • Ventricular arrhythmias
  • Bradycardia
  • Recent MI
  • CHF
  • Trying to conceive (long-term use)
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Mega Flexon Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Nausea
  • Skin rash
  • Tinnitus
  • Dryness of mouth
  • Decreased appetite
  • Mouth ulcer
  • Gastric problems
  • Palpitation
  • Dizziness
  • Abdominal discomfort
  • Constipation
  • CNS stimulation
  • Asthenia
  • Dyspepsia
  • Flushing
  • Anorexia
  • Insomnia
  • Pruritus
  • Xerostomia

Rare but more serious adverse effects may include:

  • Thrombocytopenia
  • Hypokalemia
  • Anemia
  • Hepatotoxicity
  • Anaphylaxis
  • Renal tubular necrosis, acute
  • Seizures
  • Serotonin syndrome
  • Respiratory depression
  • Hypersensitivity reaction
  • Anaphylactoid reaction
  • Stevens-johnson syndrome
  • QT prolongation
  • Dependency, abuse
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow the tablet whole immediately after opening the tablet from the strip. Do not break/crush/chew it.

Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.

Take Mega Flexon Tablet either with or without food.

For adults, the usual dosage is 1 tablet 2-3 times a day or as suggested by your physician or pharmacist.

For children: talk to your doctor before giving the tablet.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Abdominal pain
  • Yellow skin
  • Blood clotting
  • Confusion
  • Hypoglycemia
  • Lactic acidosis
Warnings and Precautions

Warnings and Precautions

Take the Mega Flexon Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Caution advised among people with renal problems. If you have any, consult your doctor before the consumption of the Mega Flexon Tablet.

Liver:

Caution advised among people with hepatic problems. If you have any, consult your doctor before the consumption of the Mega Flexon Tablet.

Pregnancy:

Paracetamol: This medicine may be used during pregnancy – no known risk of fetal harm. However, consider taking the tablet only if suggested by a doctor.

Tramadol: Do not take this medicine if you are pregnant or planning to become pregnant because consumption of this drug may lead to life-threatening withdrawal symptoms in new-born.

Lactation:

Paracetamol: This medicine may be used while breastfeeding – no known risk of infant harm based on human data. However, no human studies are available to estimate effects on milk production.

Tramadol: Do not take this drug if you are breastfeeding a baby because this drug may pass into breast milk and may harm a breastfeeding infant.

Alcohol:

Do not take Mega Flexon Tablet along with alcohol as this may increase your hepatic problems.

Driving:

Since consuming this medicine would induce sleep/cause dizziness or impair your thinking or reactions, do not drive, operate heavy machinery or involve in any works which may demand your attention/physical strength.

Drug Interactions:

Caution always advised when used with other drugs especially drugs that make you sleepy, slow your breathing, sleeping pills, muscle relaxents, sedative tranquilizer or antipsychotic medicines and drugs that affect serotonin levels in your body, etc.

Precautions
  • Keep the Mega Flexon Tablet out of reach of children.
  • Store the medicine in room temperature away from heat and moisture.
  • Do not use the Mega Flexon Tablet beyond its expiry.
  • Do not use this tablet with other forms of paracetamol-containing medications.
FDA Pregnancy Category

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant the use of the drug in pregnant women despite potential risks.


Drug Composition information
What is Paracetamol for:

It is used to used to relieve mild to moderate pain and to reduce fever.

How does Paracetamol work:

Paracetamol blocks chemicals that cause pain. It lowers fever by changing the bodys thermostat in the brain.

How should Paracetamol be used:

Take this as directed by your doctor. Do not take more than instructed by your doctor. Never take more than 1000 mg at any one time and no more than 4 times in one day. The dose for a child is different from the adult dose. Be sure to check with your doctor or pharmacist before giving this medicine to a child. It may be taken with or without food. If you need pain relief fast, take it on an empty stomach as food may slow down the absorption. You may stop taking it when you have no more pain or fever. Take it only when you need to.

Common side effects of Paracetamol :

Upset stomach or throwing up. Harm to the liver may rarely happen.

What do I do if I miss a dose

Many times this drug is taken on an as needed basis.

What precautions should I take when taking Paracetamol :

Do not take this drug if you had an allergy to this or similar drugs in the past. Do not take it if you have liver or kidney failure.

When do I need to seek medical help

Seek help if you are having an allergic reaction to the drug. Signs include rash, difficulty breathing, swelling of the lips, face, tongue; or hives. Symptoms of an overdose may include nausea; vomiting; loss of appetite; sweating; extreme tiredness; unusual bleeding or bruising; pain in the stomach; yellowing of the skin. Contact an emergency centre immediately if you suspect overdose.

Can I take Paracetamol with other medicines:

Alert your doctor if you are taking blood-thinning medicines such as warfarin.

Are there any food restrictions

Avoid Alcohol

How do I store Paracetamol :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Non-Opioid Analgesics & Antipyretics

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