This medication is a kinase inhibitor, prescribed for renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer). It decreases tumor growth and replication.
Sorafenib harms cancer cells causing their death.
It comes as a tablet to take by mouth, two times per day on an empty stomach. Adult- PO- The recommended dose is 400 mg (two 200 mg tablets) twice daily.
Low white blood cell count or low platelet count. Feeling tired or weak. High blood pressure. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Hair loss. Hair most often grows back when this drug is stopped. Not hungry. Bleeding problems. Itching. Weight loss. Belly pain. Muscle pain. Rash. Heart disease may rarely happen. Holes in the GI (gastrointestinal) tract may rarely happen.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses.
If you have an allergy to sorafenib or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are pregnant or may be pregnant. If you are breast-feeding.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain. Change in thinking clearly and with logic. Sudden change in eyesight. A fast heartbeat. Chest pain or pressure. Very bad headache. Very bad belly pain. Very upset stomach or throwing up. Very loose stools (diarrhea). Very bad swelling or pain of hands or feet. Any bruising or bleeding. Feeling very tired or weak. Numbness or tingling in your hands or feet. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Targeted Cancer Therapy
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