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Zerodol P Tablet is a non-steroidal anti-inflammatory drug and an analgesic agent generally prescribed for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It relieves one from inflammation and pain. This tablet is also used for other conditions such as fracture and dental pain. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.
The active ingredients of Zerodol P Tablet are Aceclofenac 100mg and Paracetamol (also known as Acetaminophen) 325mg.
Aceclofenac is a derivative of phenylacetic acid that withholds the participation of Cyclooxygenase compound. Cyclooxygenase is an enzyme that is responsible for the formation of prostanoids including thromboxane and prostaglandins. Prostaglandins are compounds responsible for causing the pain, fever, swelling, and redness. Thus with this mechanism, pain causing factors are eliminated.
Paracetamol (or Acetaminophen) primarily acts as an analgesic and an antipyretic agent. It also possesses anti-inflammatory properties. It produces its analgesic effects by increasing the pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.
Patients with the following conditions are suggested to seek advice from their health care professionals before taking the Zerodol P Tablet:
The following side effects may or may not occur during the usage of Zerodol P Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:
Rare but more serious adverse effects may include:
Do not exceed the dose prescribed by your doctor. Swallow the tablet whole, immediately after opening the tablet from the strip. Do not break/chew/crush the tablet.
Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.
Take the Zerodol P Tablet with or without food, preferably after food to avoid GI discomfort.
For adults, the usual dosage is 1 tablet in the morning and 1 tablet in the evening or as directed by your physician or a pharmacist.
Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:
Take the tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:
Paracetamol or Acetaminophen: May be used during pregnancy – no known risk of infant harm based on limited human data.
Aceclofenac: Do not take this drug if you are pregnant or likely to get pregnant because safety during pregnancy is not yet established.
Paracetamol or Acetaminophen: May be used during lactation – no known risk of infant harm based on human data.
Aceclofenac: Inform your doctor if you are a nursing mother because safety during lactation is not yet established.
Do not take Zerodol P Tablet along with alcoholic beverages as it may increase severe hepatic problems.
Paracetamol or acetaminophen: This drug may reduce the absorption of cholestyramine within 1 hour of administration.
Aceclofenac: Increased nephrotoxicity with diuretics.
May enhance the activity of anticoagulants.
May increase plasma methotrexate levels leading to toxicity if administered within 2-4 hr of methotrexate administration.
Category N: No information available.
It is prescribed for fever, pain and arthritis
It is a nonsteroidal anti-inflammatory drug (NSAID), that blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain and swelling
To gain the most benefit, take the medicine daily or as prescribed by your doctor. It is usually taken twice a day. Take it with food.
Indigestion, heartburn, dyspepsia, diarrhoea, nausea, abdominal pain and flatulence.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Many times this drug is taken on an as needed basis.
Inform your doctor is you suffer from history of peptic ulceration, cerebrovascular bleeding, ulcerative colitis, crohns disease, systemic lupus erythmatosus, porphyria, haematopoietic or coagulation disorders. The dose will be adjusted in people with hepatic, renal or cardiac function impairment.
Do not take the drug if you had an allergic reaction to the medication in the past. Stop taking this drug and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; rash; wheezing; itching; closing of your throat; swelling of your lips, tongue, or face; or hives).
Inform you doctor is you are taking lithium, digoxin, diuretics or ACE inhibitors. Be sure to talk to your doctor about all the drugs you take.
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category N : Not yet classified.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Non-Opioid Analgesics & Antipyretics
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