It is used for treating acute migraine headaches with or without aura (eg, dark spots, flashing lights, wavy lines).
Almotriptan is a serotonin 5-HT1 receptor agonist. It works by narrowing the blood vessels in the brain and thereby reducing pressure and pain in the brain. A migraine headache is thought to be caused by widened blood vessels exerting pressure on the brain.
Take almotriptan by mouth with or without food.
Take almotriptan with a full glass of water .
Swallow almotriptan whole. Do not break, crush, or chew before swallowing.
It is best to take a dose of almotriptan as soon as you notice symptoms of a migraine attack.
If your headache returns, a second dose may be taken. Allow at least 2 hours between doses of almotriptan.
Do not take more than 2 tablets in a 24-hour period.
Some common side effects include:
Dizziness; drowsiness; dry mouth; headache; nausea; sleepiness; vomiting.
Seek medical attention right away if any of these side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; burning, numbness, or tingling; changes in vision; chest pain; cold, pale, or blue-colored fingers or toes; confusion; fainting; fast or irregular heartbeat; one-sided weakness; seizures; severe headache, dizziness, or vomiting; severe stomach pain; shortness of breath; slurred speech; tightness, pain, or pressure in the jaw, neck, or chest; wheezing.
If you miss a dose of almotriptan and you still have a headache, follow your doctor's dosing instructions. Contact your doctor if you are not sure what to do if you miss a dose. Do not take almotriptan more often than prescribed. Do not take 2 doses at once.
Do NOT use almotriptan if:
you are allergic to any ingredient in almotriptan
you have a history of ischemic heart disease (eg, angina, heart attack), coronary artery disease (CAD), other moderate to severe heart problems, brain blood vessel disease (eg, stroke, transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)
you have uncontrolled high blood pressure or ischemic heart disease
you have hemiplegic or basilar migraine headaches
you have used certain other migraine medicines within the past 24 hours (eg, an ergot alkaloid eg, ergotamine, another serotonin 5-HT1 receptor agonist eg, eletriptan, rizatriptan)
you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
you are taking sibutramine.
Some medical conditions may interact with almotriptan. Tell your doctor if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
if you have a history of liver or kidney problems, seizures (eg, epilepsy), other types of headaches (eg, cluster headaches), or heart problems, or if a family member has had heart disease
if you have shortness of breath, chest pain, or a history of high blood pressure, heart attack, stroke, high cholesterol, diabetes, or smoking
if you are a woman who is past menopause or you have had a hysterectomy
if you are a man who is over 40 years old
if you are very overweight.
Some medicines may interact with almotriptan. Tell your health care provider if you are taking any other medicines, especially any of the following:
Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), or sibutramine because the risk of a serious side effect called serotonin syndrome may be increased. Symptoms of serotonin syndrome may include mental or mood changes, hallucinations, fast heartbeat, fever, loss of coordination, muscle spasms, increased sweating, nausea, vomiting, or diarrhea
Azole antifungals (eg, ketoconazole), ergot alkaloids (eg, ergotamine), HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, erythromycin), MAOIs (eg, phenelzine), verapamil, or another serotonin 5-HT1 receptor agonist eg, eletriptan, rizatriptan) because they may increase the risk of almotriptan's side effects.
Store almotriptan at 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep almotriptan out of the reach of children and away from pets.
Pregnancy Category: C
There are no controlled data in human pregnancy. This drug should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus .It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use almotriptan, check with your doctor. Discuss any possible risks to your baby.
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