Amixide tablet is a combination medicine used to treat mental depression associated with nervousness, tension and moderate to severe anxiety. The tablet helps many people to recover from depression by improving their mood, nerve conduction and relieving from nerve pain. However, the uses mentioned here are not comprehensive, there may be other conditions for which the medication may be used upon your doctor’s discretion.
The active ingredients of Amixide tablet are Amitriptyline 25Mg and Chlordiazepoxide 10Mg
Amitriptyline, a dibenzo cycloheptadiene tricyclic antidepressant, works by increasing the levels of chemical messengers – serotonin and norepinephrine in the brain that stops the movement of pain signals and regulates the mood and treats depression. Chlordiazepoxide is a benzodiazepine which works by increasing the action of a chemical messenger known as GABA by supressing the abnormal and excessive activity of the nerve cells in the brain.
Patients with following conditions are suggested to seek advice from their healthcare professionals before using Amixide tablet:
The following side effects may or may not occur during the usage of Amixide tablet. It is usually well tolerated when taken in the recommended dosage guidelines. Most of the side effects are generally mild and you may experience one or more of the following symptoms:
Rare but more serious adverse effects may include:
Take Amixide tablet as instructed by your doctor. Swallow the tablet whole with water, immediately after opening it from the strip. Do not break or crush or chew the tablet.
Avoid missing or forgetting the dose. If you do, take it as soon as you remember; but if it’s almost time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.
The tablet can be taken with or without food. If significant stomach upset occurs, it could be taken with food. Take the tablet at the same time every day as it helps to maintain a consistent level of medicine in the body preferably in the evening.
Do not use this medicine for durations shorter or longer than suggested by your doctor as it has a very high potential of becoming habit-forming. Continue to use this drug until completion of the maximum amount suggested. even though the symptoms disappear after the medicine has begun.
Avoid taking medicine more than the prescribed dosage. If you notice any unusual or abnormal reactions after taking the tablet, promptly seek medical attention. Depending on the dosage of Amixide tablet, symptoms vary in individuals, you may experience one or more of the following symptoms:
Use this tablet only on the advice of medical practitioner. Dose adjustments or complete avoidance of the Amixide tablet may be required in the following conditions:
Caution is advised among people with kidney problems. Close monitoring of kidney function and adjustments of dose of the medicine may be needed based on the clinical condition of the patient. If you have any renal problems, it is highly recommended that you consult doctor before the consumption of the tablet.
Extreme caution is advised among people with liver problems. Dose adjustments of the tablet may be needed. If you have any hepatic problems, it is highly recommended that you consult doctor before the consumption of this medicine. Any symptoms such as nausea, fever, dark urine etc should be reported to your doctor immediately. However, use of this medicine is not suggested in patients with moderate to severe liver diseases.
Amixide tablet is not recommended during pregnancy as it is known to cause harm to the fetus. Despite the fact that there are limited studies in human beings, animal studies have shown effects on the developing baby. It is recommended that you consult your doctor before consuming this medicine.
The medicine is likely unsafe to use for nursing mothers. Limited human data suggests that the medication may pass into the breastmilk and harm the infant. Consult your doctor immediately if the baby shows signs of increased sleepiness, breathing problems or difficulty in breast feeding.
Consumption of alcohol with Amixide tablet is not recommended as it increases side effects such as difficulty in breathing, dizziness, light headedness. Any symptoms of abnormal reactions after taking the tablet should be reported to your doctor immediately.
The tablet may decrease alertness, cause impaired judgement, affect your vision and make you feel dizzy, light headedness, so do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.
Grape fruit juice or grape fruit containing foods have shown to scale back the effect of the tablet.
Inform your doctor or pharmacist if you are taking any other medicines which includes over-the-counter drugs, herbal tonics, supplements and medicines that you buy without a prescription. Alert your doctor if you are taking Amixide tablet with sympathomimetic agents (noradrenaline, phenylephrine, phenylpropanolamine, ephedrine), antiarrhythmics (quinidine, amiodarone), anti-fungal (fluconazole, terbinafine terfenadine), anti-histamines (mizolastine, astemizole, terfenadine), diuretics (furosemide), adrenergic neuron blockers (clonidine, betanidine reserpine), calcium channel blockers, cimetidine, methylphenidate, anti-psychotics.
Category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
It is used to treat low mood (depression). It is used to stop or prevent migraine headaches. It is used to ease long-term pain problems including diabetic and other neuropathies. It is used to treat anxiety. It is used to treat eating problems. It is used to treat panic attacks.
Amitriptyline affects chemicals in the brain. With low mood (depression), sleep and eating habits may get better fast. Other signs may take up to 4 to 6 weeks to get better.
Take Amitriptyline exactly as directed by your doctor. Do not take more or less than instructed by your doctor. - You may take Amitriptyline with or without food. - Amitriptyline must be taken regularly for it to work well. You may see the benefits of Amitriptyline only after 2-4 weeks. Do not be discouraged if you do not feel better soon after taking the medicine. Do not stop taking Amitriptyline unless instructed by your doctor. You may feel unwell if Amitriptyline is stopped suddenly.
Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly; Feeling dizzy; Hard stools (constipation); Dry mouth; Change in color of urine to blue or green
Take a missed dose as soon as you think about it. - If it is close to the time for your next dose, skip the missed dose and go back to your normal time. - Do not take 2 doses at the same time or extra doses. - Do not change the dose or stop this drug. - Talk with the doctor.
Alert your doctor if you have bipolar disorder, mania, heart disease or severe liver disease. - It is also important to let your doctor know if you are pregnant, planning to get pregnant, or breastfeeding. - Alert your doctor if you have taken other mood medicines known as monoamine oxidase inhibitors (MAOIs) in the last 14 days. - Some examples of MAOIs include phenelzine, moclobemide and tranylcypromine. - Alert your doctor if you are being treated with a gastric reflux medicine known as cisapride.
Seek help if you think there was an overdose or signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Seek help if you are planning to harm yourself or the want to harm yourself gets worse. - A fast heartbeat. - Very bad dizziness or passing out. Change in thinking clearly and with logic. - Not able to pass urine. - Feeling very tired or weak. - Very nervous and excitable. - Any rash. Side effect or health problem is not better or you are feeling worse.
Alert your doctor if you are taking any of these medicines: - monoamine oxidase inhibitors (also used to treat depression) such as moclobemide, phenelzine, and tranylcypromine. - cisapride (a gastric reflux medicine). - selegiline (a medicine for Parkinson’s disease). - linezolid (an antibiotic). - artemether and lumefantrine (malaria medicines). You will also need to inform your doctor if you are taking any of these: - other antidepressants, sedatives or anxiety medicines. - any other mood medicines. - epilepsy medicines. - blood pressure medicines such as gaunethidine, debrisoquine, betanidine and clonidine - anticholinergics, commonly used to treat runny nose, allergies, travel sickness, such as chlorpheniramine, promethazine, hydroxyzine, and dimenhydrinate. - cimetidine (a stomach medicine). - heart medicines such as quinidine and flecainide. - disulfuram (a medicine used to treat alcoholism). - painkillers such as tramadol, morphine or fentanyl Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.
Store in a cool, dry place, protected from light, and away from the reach of children. - Medicines must not be used past the expiry date. - If you have been given Amitriptyline syrup, throw it away 6 months after opening.
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
The tablet is a combination medicine used to treat mental depression associated with nervousness, tension and moderate to severe anxiety. The tablet helps many people to recover from depression by improving their mood, nerve conduction and relieving from nerve pain.
The tablet is well tolerated when taken in prescribed dosage guidelines. Most common side effects include diarrhea, constipation, dry mouth, increased or decreased appetite, nausea, vomiting, epigastric distress, headache, dizziness, decreased sexual urge, unexpected weight loss or gain. Its use may also lead to extreme but uncommon side effects such as slurred speech, seizures, jaundice, hypertension or hypotension, urinary retention, arthralgia, excessive weakness and tiredness, bleeding abnormalities, gynaecomastia, testicular swelling, haemorrhage.
Take the tablet with or without food. If significant stomach upset occurs, you could take with food.
If you ever had impaired kidney function, sever liver impairment or heart disease, let your doctor know before taking this medicine. Inform your doctor about all the medicines you take to ensure that you are healthy. This medicine is contraindicated in patients with hypersensitivity to any of the ingredients used in the tablet, concomitant use with Monoamine oxidase inhibitors, arrhythmias, recent myocardial infarction, coronary artery insufficiency, severe hepatic impairment, pregnancy and lactation. Caution is advised among patients with history cardiovascular disease and seizures, brain damage, narrow angle glaucoma, urinary retention, diabetes mellitus, alcoholism, hyperthyroidism, paralytic ileus, head trauma, paranoid symptomology, elderly and debilitated patients.
The tablet may decrease alertness, cause impaired judgement, affect your vision and make you feel dizzy, difficulty in concentration, fatigue, light headedness, so do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.
The tablet is usually well tolerated when taken in the recommended dosage guidelines. Over dose of the medicine may lead to CNS depression, convulsions, excitement, cardiac dysrhythmias, restlessness, intestinal statis mydriasis, severe hypotension, dry mucous membranes, respiratory depression.
The tablet is not recommended during pregnancy as it is known to cause harm to the fetus. Despite the fact that there are limited studies in human beings, animal studies have shown effects on the developing baby. It is recommended that you consult your doctor before consuming this medicine.
No, do not take the medicine without doctor’s prescription.
Consumption of alcohol with this medicine is not recommended as it increases side effects such as difficulty in breathing, dizziness, light headedness. Any symptoms of abnormal reactions after taking the tablet should be reported to your doctor immediately.
Store the medicine at room temperature (20-30 degree Celsius) in a cool and dry place. Keep the tablet according to the instructions mentioned on the pack or label. Store the medicine in the container or the pack it came in, tightly closed.
This tablet is designed to be swallowed with water. If you take them in a way they weren’t intended to be used, you could experience an overdose if the active constituent enters the blood stream too quickly. Alternatively, if it enters your body too slowly, it may never achieve a high enough concentration to be completely functional.
This tablet is not recommended for children below 6 years of age since the safety and efficacy of use are not clinically established.
The amount of time required for this medicine to show its action in the body is 2-6 hours after administration.
The amount of time for which this medicine remains active in the body is for 13-36 hours.
Medicines should always be taken under medical supervision. Take the medicine exactly as prescribed by your doctor: for dosage and duration. Most recommended dose is one tablet per day.
The number of days that any medicine must be taken varies from patient to patient; and case to case. So always stick to your doctor’s suggestion about how many days to take this medicine.
Use the medicine exactly as prescribed by your doctor for the dosage and duration. Take the medicine at the same time every day preferably in the evening.
Note: All of the above information is for reference purpose only. It is always recommended that you consult a medical professional.
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