Country of origin: INDIA
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Bionesp 25MCG injection belongs to erythropoiesis stimulating agents, is used to treat anaemia (low count of red blood cells) caused by kidney failure (a condition where your kidneys stop functioning over a period and cannot produce enough erythropoietin hormone responsible for formation of RBC) or chemotherapy (medicines used to treat cancer). This medicine works by boosting the bone marrow (the spongy tissue in the centre of the bones) to increase the production of red blood cells. It is not recommended for use in patients below 18 years of age. However, the uses of this injection mentioned here are not comprehensive, there may be other conditions for which the medication may be used upon your doctor’s discretion.
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The active ingredient of Bionesp 25MCG injection is Darbepoetin alfa 25MCG
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Darbepoetin alfa is an erythropoiesis stimulating agent that works by stimulating the bone marrow (the spongy tissue in the centre of the bones) to increase the production of red blood cells.
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Patients with following conditions are suggested to seek advice from their healthcare professionals before using Bionesp 25MCG injection:
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Bionesp 25MCG injection is usually well tolerated when taken in the prescribed dosage guidelines. Most of the side effects are generally mild and you may experience one or more of the following symptoms:
Rare but more serious adverse effects may include:
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Do not self-administer Bionesp 25MCG injection, your nurse or trained physician will give you the medicine. Follow all the instructions given by your doctor carefully. Continue to take the medicine till the time you see an improvement in your health conditions or as advised by your doctor. If a dose is missing, it should be taken as soon as possible.
The injection can be taken with or without food.
Do not change the dose or stop taking the medicine before completion of the course or without consulting your doctor. Continue to use this drug until completion of the maximum amount suggested even though the symptoms disappear after the medicine has begun.
Avoid taking Bionesp 25MCG injection more than the prescribed dosage. Since this injection will be given by doctor or nurse, therefore it is less likely that you will receive overdose of the medicine. If there should be an occurrence of unplanned excess, look for any new signs or symptoms. Overdose of the medicine may lead to increase in platelet count.
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Use Bionesp 25MCG injection on the advice of medical practitioner. Complete avoidance of the medication may be required in the following conditions:
It is safe to use in patients with kidney disease. No dose adjustments of the medicine are needed. However, if you have any renal problems, it is highly recommended that you consult your doctor before taking this medicine.
The injection should be used with caution in patients with moderate and severe liver disease. Close monitoring of liver function and adjustments of dose of the medicine may be needed based on the clinical condition of the patient. We highly recommend that you consult your doctor before the use. However, use of this medicine is not recommended for patients with severe hepatic impairment.
It is not considered safe to use in pregnant women unless the potential benefits outweigh the risks involved. Despite the fact that there are limited studies in human beings, animal studies have shown adverse effects on the developing baby. It is recommended that you consult your doctor before taking this injection.
This medication is passed to infants through mother’s milk. Breastfed infants should be closely monitored. Since limited information is available about the safety of taking this injection, consult your doctor if you are nursing mother and stay on the safe side.
Interaction of alcohol with this injection is unknown. Any symptoms of abnormal reactions after taking the medicine should be reported to your doctor immediately.
The medicine does not cause drowsiness or dizziness. If you notice any abnormal reactions after taking the medicine do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.
There are no known food interactions with this injection.
All medicines interact differently for person to person. Inform your doctor or pharmacist if you are taking any other medicines which includes over-the-counter drugs, herbal tonics, supplements and medicines that you buy without a prescription. Alert your doctor if you’re taking Bionesp 25MCG injection along with rifampicin, cyclosporine, thalidomide, ramipril, lenalidomide.
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Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
This medication is an erythropoiesis-stimulating agent, prescribed for anemia due to chronic kidney disease. It stimulates the bone marrow to produce more red blood cells.
Darbepoetin alpha fires up the bone marrow to make red blood cells
SCIV- The initial dose is 0.45 mcgkg body weight, as a single injection once weekly. For patients not receiving dialysis: The initial dose is 0.75 mcgkg as a single injection once every 2 weeks. It comes as a solution for injection to be administered by a healthcare provider into the vein or under the skin.
High or low blood pressure. Swelling. Irritation where the shot is given. Belly pain. Cough.
Many times this drug is taken on an as needed basis.
If you have an allergy to darbepoetin alfa or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have very high blood pressure. If you have a kind of anemia called Pure Red Cell Aplasia (PRCA). If you have a latex allergy, talk with your doctor.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Chest pain or pressure or a fast heartbeat. Trouble breathing. Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight. Very bad dizziness or passing out. Swelling, warmth, or pain in the leg or arm. Seizures. Very bad headache. Feeling very tired or weak. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Avoid Alcohol
Store it at room temperature.
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Haematopoietic Agents
It is used to treat anaemia (low count of red blood cells) caused by kidney failure (a condition where your kidneys stop functioning over a period and cannot produce enough erythropoietin hormone responsible for formation of RBC) or chemotherapy (medicines used to treat cancer). This medicine works by boosting the bone marrow (the spongy tissue in the centre of the bones) to increase the production of red blood cells. It is not recommended for use in patients below 18 years of age.
The injection is well tolerated when taken in prescribed dosage guidelines. Most common side effects include injection site reactions (pain, redness, swelling), high blood pressure, blood clots (thrombosis), fluid retention (oedema), skin rash and itching, difficulty in breathing and swallowing, cough, anxiety, pale skin, excessive tiredness and weakness, dizziness and fainting, diarrhoea. Its use may also lead to uncommon side effects such as irregular heartbeat, convulsions (seizures).
The injection can be taken with or without food.
Tell your doctor if you have an allergy to any ingredients used in the injection. Inform your doctor about all the medicines you take to ensure that you are healthy. This medicine is contraindicated in patients with hypersensitivity to any of the components used in the injection, uncontrolled hypertension, blood disorders (pure red cell aplasia), hepatic impairment. Caution is advised among patients with ongoing cancer treatment, history of seizures, sickle cell anaemia, cardiovascular disorders, surgery of heart and blood vessels, haemodialysis, blood clotting disorders, renal impairment, children, pregnancy and lactation.
The medicine does not cause drowsiness or dizziness. If you notice any abnormal reactions after taking the medicine do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.
The injection is usually well tolerated when taken in the recommended dosage guidelines. Since this injection will be given by doctor or nurse, therefore it is less likely that you will receive overdose of the medicine. Overdose of the medicine may lead to increase in platelet count.
It is not considered safe to use in pregnant women unless the potential benefits outweigh the risks involved. Despite the fact that there are limited studies in human beings, animal studies have shown adverse effects on the developing baby. It is recommended that you consult your doctor before taking this injection.
No, do not take the medicine without doctor’s prescription.
Interaction of alcohol with this injection is unknown. Any symptoms of abnormal reactions after taking the medicine should be reported to your doctor immediately.
Store the medicine at room temperature (2-8 degree Celsius) in a cool and dry place. Do not freeze. Keep the injection according to the instructions mentioned on the pack or label. Store the medicine in the container or the pack it came in, tightly closed.
If given according to the directions given by your doctor, it is safe to be used in children.
The amount of time required for this medicine to show its action in the body is cummulative and generally takes up to 2-6 weeks for the result to be observed.
The amount of time for which this medicine remains active in the body is clinically not known.
Medicines should always be taken under medical supervision. Take the medicine exactly as prescribed by your doctor: for dosage and duration.
The number of days that any medicine must be taken varies from patient to patient; and case to case. So always stick to your doctor’s suggestion about how many days to take this medicine.
Use the medicine exactly as prescribed by your doctor for the dosage and duration.
Note: All of the above information is for reference purpose only. It is always recommended that you consult a medical professional.
BIOCON LIMITED
20th km, hosur road, electronic city,bangalore, india 560 100
BIOCON LIMITED
20th km, hosur road, electronic city,bangalore, india 560 100
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