This medication is an antipsychotic, prescribed for schizophrenia. It changes the activity of certain natural substances in the brain.
Clozapine helps clear thinking. It works on helping social interactions, mood, expression of mood, as well as, delusions, paranoia, and look.
The initial dose is 12.5 mg two timesday, and the dose is increased by 25–50 mg each day, until the dose reaches 300–450 mg per day. The usual dosage range is 300–600 mg per day. Maximum: 900mgday. It comes as a tablet to take by mouth, with or without food.
High blood sugar. This most often goes back to normal when drug is stopped. Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Nervous and excitable. Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative. Weight gain. Change in sex ability. This most often goes back to normal. Drooling when sleeping. Harm to the heart may rarely happen.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.
Alert your doctor if you have any of these conditions. Clozapine may or may not be suitable for you if you have any of these conditions. - bone marrow disease. - low white blood cell count. - epilepsy (fits). - bowel blockage or bowel paralysis (paralytic ileus) which causes severe constipation. - other bowel diseases. - heart, liver or kidney disease. - mental illness caused by alcohol or drug addiction. Alert your doctor if you have taken Clozapine in the past and let him know if Clozapine has ever given you any problems. Clozapine is not suitable for elderly people with psychosis that is related to dementia.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. - Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain. - Very bad dizziness or passing out. - Trouble breathing. - A fast heartbeat. - Big change in balance. - Very bad headache. - Feeling very tired or weak. - Very bad swelling. - A big weight gain. - More trips to the bathroom, more thirst, or weight loss. - For women, if you get pregnant while taking this drug. - Any rash. - Side effect or health problem is not better or you are feeling worse.
Alert your doctor if you are taking any medicines that may cause bone marrow suppression or a decreased white blood cell count. Some examples of such medicines are cancer medication, antibiotics like chloramphenicol, cotrimoxazole and sulfonamides, certain painkillers such as phenylbutazone, and an arthritis medication called penicillamine. There are many other medicines that may lower your white blood cell count or cause bone marrow suppression. Always ask your doctor or pharmacist if you are not sure. Alert your doctor if you are taking any of these medicines: - sleeping pills such as diazepam, alprazolam or similar. - diabetes medicines - certain heart medicines such as digoxin. - blood-thinners such as warfarin. - mood medicines such as citalopram or risperidone. - medicines that can cause drowsiness such as opioid painkillers (e.g. morphine), antihistamines. - high blood pressure medicines - metoclopramide (medicine used to treat nausea or vomiting). - antibiotics such as norfloxacin or ofloxacin. - omeprazole (gastric medicine) - epilepsy (fits) medicines such as valproic acid, phenytoin or carbamazepine. - certain mood medicines such as lithium. - nicotine-containing products such as cigarettes and anti-smoking patches. Always alert your doctor or pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.
Avoid alcohol. - Alcohol will worsen the dizziness and drowsiness caused by Clozapine.
Keep this medication in the container it came in and out of the reach of children.
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
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