CYCLOPAM TAB

Uses and Benefits

Cyclopam Tablet is used as an antispasmodic medicine to relieve one from menstrual bleeding, intestinal, renal, or biliary colic associated with vomiting, and also relieves from menstrual pain, cramps in the stomach, and abdomen pain. In addition, this also relieves from severe colic and also relaxes the muscles in the stomach and intestine. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.

Composition

The active ingredients of Cyclopam Tablet are Dicyclomine (also known as Dicycloverine) 20mg and Paracetamol (also known as Acetaminophen) 500mg.

Mechanism of Action of Drugs

Dicyclomine (or Dicycloverine) is an anticholinergic drug that reduces muscle spasms in the gastrointestinal tract through a process of nonselective smooth muscle relaxation. An anticholinergic agent is basically a substance which blocks the neurotransmitter acetylcholine in both central and peripheral nervous systems. It inhibits the parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.
Paracetamol (or Acetaminophen) primarily acts as an analgesic and an antipyretic agent. It also possesses anti-inflammatory properties. It produces its analgesic effects by increasing the pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professional before taking Cyclopam Tablet:

• Hypersensitivity to any of the components used in Cyclopam Tablet such as Dicyclomine (Dicycloverine) and paracetamol (Acetaminophen)
• Glaucoma
• GI Bleeding
• Active peptic ulcer disease
• Renal or heart failure(Severe)
• Hepatic impairment
• Coagulation disorder

• Caution:
• Psychosis
• Hiatal hernia
• Prostate hypertrophy
• Hepatic impairment(Mild-Moderate)
• Active hepatic disease(Mild-Moderate)
• Hypovolemia(Severe)
• Malnutrition(Severe)
• Chronic alcohol use

Side and Adverse Effects

The following side effects may or may not occur during the usage of this Cyclopam Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

• Nausea
• Vomiting
• Dizziness
• Rash
• Asthenia
• Palpitation
• Headache
• Insomnia
• Constipation
• Pruritis
• Agitation
• Edema
• Dizziness
• Drowsiness

Rare but more serious adverse effects may include:

• Psychosis
• Delirium
• Hallucinations
• Anaphylaxis
• Paralytic ileus
• Fatal hepatitis
• Stevens-johnson syndrome
• Anaphylaxis
• Hepatotoxicity
• Renal tubular necrosis(Acute)
• Anemia
• Hypokalemia
• Thrombocytopenia
• Analgesic associated nephropathy (chronic use)

How to Use

Do not exceed the dose prescribed by your doctor.
Swallow the Cyclopam Tablet whole, immediately after opening the tablet from the strip.
Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t consume two doses at the same time which is dangerous to your health.
Cyclopam Tablet may be taken with or without food.
Do not exceed more than 3 tablets in a day except on the advice of a medical practitioner or take it as directed by your physician.

Warnings and Precautions

Take the Cyclopam Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Caution advised among people with renal problems. If you have any, consult your doctor before the consumption of this Cyclopam Tablet.

Liver:

Caution advised among people with hepatic problems. If you have any, consult your doctor before the consumption of Cyclopam Tablet.

Pregnancy:

May be used during pregnancy – there is no known risk of fetal harm based on human data with short term use.

Lactation:

Dicyclomine or Dicycloverine: This drug may pass through breast milk and may cause breathing problems in breastfed infants younger than 6months. Therefore, inform your doctor if you are breastfeeding an infant during the treatment.
Paracetamol (Acetaminophen): May be used during pregnancy – no known risk for breastfed infants based on human studies with oral form. However, no human data available to evaluate effects on milk production.

Alcohol:

Avoid taking alcohol. This may increase your hepatic risk.

Driving:

Since consuming this medicine would impair your thinking or reactions or it may also cause blurred vision, do not drive, operate heavy machinery or involve in any works which may demand your attention/physical strength.

Drug Interactions:

Caution always advised when used with other OTC drugs and herbal supplements. Tell your doctor about your current list of medication or if any other medicines which you carry on with or discontinued.

FDA Pregnancy Category

Category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.