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      Mfg/Mkt: sanofi india limited

      DEPAKOTE XR 500MG TAB

      Country of origin: INDIA

      Seller Information

      15 Units/pack

      MRP 324.12

      Inclusive of all Taxes

      FLAT 20% OFF On bills above 1000.0
      DEPAKOTE XR 500MG TAB

       Depakote XR Tablet 500mg
      Uses and Benefits

      Uses and Benefits

      Depakote XR Tablet 500mg is used to treat prophylaxis of migraine, acute manic episodes of bipolar disorder, and complex partial seizures. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion during the treatment.

      Composition

      Composition

      The active ingredient of Depakote XR Tablet 500mg is Divalproex Sodium 500mg.

      Mechanism of Action of Drugs

      Mechanism of Action of Drugs

      Divalproex sodium balances certain chemicals in the brain thus helps to reduce the excitability of several nerves. This is how, it helps to treat seizure, manic episodes and prevents headaches.

      Contraindications and Cautions

      Contraindications and Caution

      Patients with the following conditions are suggested to seek advice from their health care professionals before taking the Depakote XR Tablet 500mg:

      • Hypersensitivity to any of the ingredients used in the Depakote XR Tablet 500mg such as Divalproex Sodium
      • Significant hepatic impairment
      • Urea cycle disorders
      • Mitochondrial disorder
      • Mitochondrial disorder, suspected
      • Avoid abrupt withdrawal
      • Caution:
      • Pediatric patients
      • Female patients of reproductive potential
      • Renal impairment
      • Organic brain disease
      • Head injury
      • Mental retardation with a seizure disorder
      • Congenital metabolic disorder
      • Multiple anticonvulsant treatments
      • Myelosuppression
      • Bleeding risk
      • Depression or history
      • Hepatic disease history
      • GI transit time decreased.
      Side Effects

      Side and Adverse Effects

      The following side effects may or may not occur during the usage of this Depakote XR Tablet 500mg. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

      • Headache
      • Nausea
      • Vomiting
      • Asthenia
      • Somnolence
      • Thrombocytopenia
      • Dyspepsia
      • Dizziness
      • Diarrhea
      • Abdominal pain
      • Tremor
      • Alopecia
      • Weight changes
      • Appetite changes
      • Constipation
      • Nervousness
      • Emotional liability
      • Insomnia
      • Peripheral edema
      • Rash
      • Depression
      • Dyspnea
      • Tinnitus
      • Amnesia
      • Abnormal gait
      • Vision changes
      • Blurred vision
      • Nystagmus
      • Myalgia
      • Photosensitivity
      • Medication residue in stool

      Rare but more serious adverse effects may include:

      • Hepatotoxicity
      • Pancreatitis
      • SIADH
      • Hyponatremia
      • Pancytopenia
      • Thrombocytopenia
      • Drug reaction with eosinophilia and systemic symptoms
      • Hyperammonemia
      • Hypothermia
      • Myelosuppression
      • Aplastic anemia
      • Bleeding
      • Erythema multiforme
      • Stevens-johnson syndrome
      • Toxic epidermal necrolysis
      • Anaphylaxis
      • Hallucinations
      • Psychosis
      • Suicidality
      • Encephalopathy
      • Coma
      • Parkinsonism
      How to Use

      How to Use

      Do not exceed the dose prescribed by your doctor. Swallow the tablet whole immediately after opening it from the strip. Do not break or chew it.
      Avoid missing/forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t consume two doses at the same time which may be dangerous to your health.
      Take the medicine at the prescribed time and dosage.

      Overdosage

      Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience any one or more of the following signs or symptoms:

      • Somnolence
      • CNS depression
      • Heart block
      • Deep coma
      • Respiratory insufficiency
      • Multiple organ failure
      • Death
      Warnings and Precautions

      Warnings and Precautions

      Take the Depakote XR Tablet 500mg only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

      Pregnancy:

      This medicine is contraindicated in pregnancy. However, consider taking the tablet only if the benefits outweigh the risks.

      Lactation:

      safety during pregnancy is unknown. Therefore, inform your doctor if you are a nursing mother before taking the tablet.

      Drug Interactions:

      Caution always advised when used with other medicines. Therefore, inform your doctor about your current list of medicines (if you use any) during the treatment.

      Precautions
      • Keep the medicine out of sight and reach of children.
      • Store at room temperature away from heat and moisture.
      • Do not use the medicine beyond its expiry.
      FDA Pregnancy Category

      FDA Pregnancy Category

      Category X: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in the use of the drug in pregnant women outweigh potential benefits.


      Drug Composition information
      What is Divalproex Sodium for:

      This medication is an anticonvulsant, prescribed for bipolar disorder, epilepsy and to prevent migraine headache. It controls the abnormal activity of nerve impulses in the brain and central nervous system.

      How does Divalproex Sodium work:

      Valproic acid and derivatives help clear thinking. It raises a chemical called gamma-aminobutyric in the brain. This chemical calms the brain. It helps steady mood.

      How should Divalproex Sodium be used:

      Adult: PO- Partial seizures; Primary generalized seizures- Initial-10-15 mgkgday in 2-4 divided doses. Max: 60 mgkgday. Acute manic episodes of bipolar disorder- Initial- 25 mgkg once daily. Max: 60 mgkgday. Migraine prophylaxis- 500 mg once daily for 1 wk, up to 1,000 mg once daily. It comes as a tablet to take by mouth, with food.

      Common side effects of Divalproex Sodium :

      Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Headache. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Belly pain. Hair loss. Muscle weakness. Twitching. Not able to sleep.

      What do I do if I miss a dose

      Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. This could cause seizures. Talk with your doctor.

      What precautions should I take when taking Divalproex Sodium :

      If you have an allergy to valproic acid or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have liver disease. If you are pregnant or may be pregnant. If you are breast-feeding.

      When do I need to seek medical help

      If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad belly pain. Very upset stomach or throwing up. Not able to eat. Dark urine or yellow skin or eyes. Feeling very tired or weak. Any rash. Side effect or health problem is not better or you are feeling worse.

      Can I take Divalproex Sodium with other medicines:

      Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

      Are there any food restrictions

      Avoid Alcohol

      How do I store Divalproex Sodium :

      Oral: Store it at controlled room temperature (15-30°C).

      Pregnancy Category

      Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

      Therapeutic Classification

      Antipsychotics, Anticonvulsants, Antimigraine Preparations

      Seller Information
      Manufactured By

      SANOFI INDIA LIMITED

      gala no 3,4,5,6b & 6c,7f city link warehsg,complex building no 120-121 vill.vadpe bhiwandi-thane 421302,mahrashtra,india

      Packed By

      SANOFI INDIA LIMITED

      gala no 3,4,5,6b & 6c,7f city link warehsg,complex building no 120-121 vill.vadpe bhiwandi-thane 421302,mahrashtra,india

      Applicable Offers

      • 20% Discount
        On prescription medicines, orders above Rs 1000 T & C

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