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DOLONEX 40MG 2ML INJ

Country of origin: INDIA

1 Units/pack

MRP 53.12

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Dolonex Injection 40mg/2ml
Uses and Benefits

Uses and Benefits

Dolonex Injection 40mg/2ml is used in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, and also relieves from pain and inflammation. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.

Composition

Composition

The active ingredient of Dolonex Injection 40mg/2ml is Piroxicam 20mg/ml.

Mechanism of Action of Drugs

Mechanism of Action of Piroxicam

Piroxicam is a non-steroidal anti-inflammatory drug which reversibly withholds the Cyclooxygenase-1 and 2 enzymes, therefore, this leads to decreased production of pain and inflammation causing precursors such as prostaglandin.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before using the Dolonex Injection 40mg/2ml:

  • Hypersensitivity to any of the components used in the Dolonex Injection 40mg/2ml such as Piroxicam
  • Asthma type reactions to piroxicam, Aspirin or other NSAID’S
  • GI ulceration
  • Ulcerative colitis
  • Caution:
  • In elderly or debilitated patients
  • Renal impairment
  • Hepatic impairment
  • Asthma
  • Recent MI
  • Cardiovascular disease
  • Cardiac disease risk
  • HTN
  • CHF
  • Fluid retention
  • Coagulation disorder
  • GI bleeding or Ulcer
  • Dehydration
  • Alcohol use
  • Smoking
  • Prolonged use
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of this Dolonex Injection 40mg/2ml. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Dyspepsia
  • Nausea
  • Abdominal pain
  • Constipation
  • Headache
  • Dizziness
  • Somnolence
  • Rash
  • ALT AST Elevated
  • Edema
  • Fluid retention
  • Tinnitus
  • Photosensitivity
  • Ecchymosis
  • Decreased Female fertility
  • Delayed ovulation

Rare but more serious adverse effects may include:

  • GI Bleeding
  • GI perforation, ulcer
  • MI
  • Stroke
  • Thromboembolism
  • HTN
  • CHF
  • Renal papillary necrosis Nephrotoxicity
  • Hepatotoxicity
  • Bronchospasm
  • Exfoliative dermatitis
  • Steven-johnson syndrome
  • Toxic epidermal necrolysis
  • Anemia
  • Blood dyscrasias
  • Prolonged bleeding time
  • Hyperkalemia
How to Use

How to Use

This medication is usually administered through parenteral route in a clinic or a hospital setting under the supervision of a nurse or a physician.

If self-administered, take the injection at prescribed time and dose.

Sterilize the area before taking the shot with an antiseptic swab. Pull the needle cap out and take the liquid from the vial/ampoule through the syringe.
Spread the skin at the site of injection using your hand. Slowly dart the needle into the site where the shot needs to be given at a 30-degree angle.
Ensure the needle is appropriately placed in the blood vessel and slowly pull back the plunger. Now, inject the solution slowly into the spot and once done, quickly remove the needle. To finish, press gently at the site with an alcohol swab.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice.Depending on the dosage, symptoms may vary but you may experience any one or more of the following signs or symptoms:

  • Lethargy
  • Drowsiness
  • Nausea
  • Vomiting
  • Epigastric pain
  • GI bleeding
  • Anaphylactoid reactions
  • HTN
  • Respiratory depression
Warnings and Precautions

Warnings and Precautions

Take Dolonex Injection 40mg/2ml only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Kidney:

Caution advised among people with renal problems. If you have any, it is highly recommended that you consult your doctor before using Dolonex Injection 40mg/2ml medicine.

Liver:

Caution advised among people with hepatic problems. If you have any, it is highly recommended that you consult your doctor before using Dolonex Injection 40mg/2ml.

Pregnancy:

This medicine is not recommended for the people who are pregnant or planning to get pregnant especially In the last trimester because this medicine is expected to cause harm to an unborn.

Lactation:

Inform your doctor if you are a nursing mother because this drug may pass into breast milk and may harm a breastfed infant.

Alcohol:

Do not drink alcohol if you are taking this injection because alcohol may increase the risk of stomach bleeding.

Drug Interactions:

Caution always advised when used with other medicines. Therefore, inform your doctor about your previous and current list of medicines which you start or stop.

Precautions
  • Keep Dolonex Injcetion 40mg/2ml out of sight and reach of children.
  • Store at a temperature below 300 C away from heat and moisture.
  • Do not use Dolonex Injection 40mg/2ml beyond its expiry.
  • Do not use the medicine if any particles are floating in it.
FDA Pregnancy Category

FDA Pregnancy Category

Category C: (Prior to 30-week gestation) Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Category D: (Starting at 30-week gestation)There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Drug Composition information
What is Piroxicam for:

Used to relieve symptoms in Rheumatoid and Osteoarthritis and Dysmenorrhea

How does Piroxicam work:

Piroxicam blocks chemicals that cause pain and swelling.

How should Piroxicam be used:

It comes as a capsule to take by mouth, with or without food. The recommended dose is 20 mg given orally once per day.

Common side effects of Piroxicam :

Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Belly pain or heartburn. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Piroxicam :

If you have an allergy to piroxicam or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of the following health problems: Very bad kidney disease, very bad liver disease, very weak heart, or ulcers. If you are more than 24 weeks pregnant.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad dizziness or passing out. Chest pain or pressure. Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight. Very upset stomach or throwing up. Very bad belly pain. Very bad swelling or pain of hands or feet. A big weight gain. Black, tarry, or bloody stools. Blood in the urine. Any bruising or bleeding. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Piroxicam with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Piroxicam :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Non-Opioid Analgesics & Antipyretics

Applicable Offers

  • 20% Discount
    On prescription medicines, orders above Rs 1000 T & C
  • 10% Discount
    On prescription medicines, orders above Rs 200 T & C

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