EMPRAZ D 40MG CAP

Uses and Benefits

Empraz D 40Mg capsule is an anti-ulcer and anti-emetic medicine used to treat indigestion and conditions where the stomach produces too much acid. It is prescribed for treating peptic ulcers, gastroesophageal reflux disease, dyspepsia, functional gastrointestinal motility disorders (slow gastric emptying) and Zollinger-Ellison syndrome. It also treats stomach and intestinal ulcers, symptoms associated with idiopathic or diabetic gastroparesis, interactable nausea and vomiting, heartburn, fullness of stomach and other conditions. It relieves stress ulcers as well as acidity caused by painkillers. However, the uses mentioned are not exhaustive, there may be other conditions for which the medication may be used upon your doctor’s discretion.

Composition

The active ingredients of Empraz D 40Mg capsule are Esomeprazole (40Mg) and Domperidone (30Mg)

Mechanism of Action of Drugs

Esomeprazole, a proton pump inhibitor and anti-ulcer, stops the action of proton pumps that are found on the cells that line the stomach there by reducing the amount of acid in the stomach and helps in acid related indigestion. Domperidone works by blocking certain chemicals in the brain that controls nausea or vomiting. It acts on upper digestive tract of stomach and intestine which causes faster gastric emptying permitting food to move easily through the stomach.

Contraindications and Caution

Patients with following conditions are suggested to seek advice from their healthcare professionals before taking Empraz D 40Mg capsule:

• Hypersensitivity to any of the active ingredients used in the capsule
• Concomitant use with erythromycin, protease inhibitors and ketoconazole medicines
• Tumour of pituitary gland
• Cardiovascular disorders

• Caution:
• Gastric malignancy
• Osteoporosis
• Lupus erythematosus
• Vitamin B12 deficiency
• Electrolyte imbalance
• Renal and hepatic impairment
• Pregnancy and lactation

Side and Adverse Effects

The following side effects may or may not occur during the usage of Empraz D 40Mg capsule. It is usually well tolerated when taken in the prescribed dosage guidelines. You may experience one or more of the following common side effects:

• Abdominal pain
• Diarrhea
• Increased liver enzymes
• Peripheral oedema
• Headache
• Nausea
• Dizziness
• Vertigo
• Insomnia
• Vomiting
• Breast pain and tenderness
• Dyspepsia
• Dry mouth
• Decreased sexual urge

Rare but more serious adverse effects may include:

• Disrupted menstrual cycle
• Fever
• Joint pain
• Sore throat
• Osteoporosis related fractures
• Vitamin B12 deficiency

How to Use

Take Empraz D 40Mg capsule as instructed by your doctor. Swallow the capsule whole with water, immediately after opening it from the strip. Do not break or crush or chew the capsule.
Avoid missing or forgetting the dose. If you do, take it as soon as you remember; but if it’s almost time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.
The capsule should be taken on an empty stomach at least 1 hour before meals as food may reduce the absorption of the medicine. Take the capsule at the same time every day as it helps to maintain a consistent level of medicine in the body.
Do not change the dose or stop taking the medicine before completion of the course or without consulting your doctor. Continue to use this drug until completion of the maximum amount suggested.

Warnings and Precautions

Take Empraz D 40Mg capsule only on the advice of medical practitioner. Dosage adjustments or complete avoidance of the medication may be required in the following conditions:

Kidney:

This capsule is likely safe to use in patients with renal impairment. Dose adjustments of the medicine may not be needed. If you have any renal problems, it is highly recommended that you consult your doctor before the consumption of this medicine.

Liver:

Extreme caution is advised among people with liver problems. Dose adjustments of the capsule may be needed. If you have any hepatic problems, it is highly recommended that you consult doctor before the consumption of this medicine. However, use of this medicine is not suggested in patients with moderate to severe liver diseases. Any symptoms such as fever, dark urine etc should be reported to your doctor immediately.

Pregnancy:

Use of Empraz D 40Mg capsule is not considered safe to use in pregnant women unless the potential benefits outweigh the risks involved. Despite the fact that there are limited studies in human beings, animal studies have shown effects on the developing baby. We recommend that you to consult your doctor before consuming the capsule.

Lactation:

The medicine is likely unsafe to use for nursing mothers. Limited human data suggests that the medication may pass into the breastmilk. Breastfed infants should be closely monitored. Since limited information is available about the safety of taking this capsule, consult your doctor if you are nursing mother and stay on the safe side.

Alcohol:

Consumption of alcohol with Empraz D 40Mg capsule is not recommended as it increases side effects of the capsule. If you consume alcohol on regular basis, relevant dose adjustments may be necessary depending on your clinical condition.

Driving:

The capsule may decrease alertness, cause impaired judgement, affect your vision and make you feel dizzy, light headedness, so do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.

Food:

Caffeine, spicy and fatty foods and grape fruit juice should be avoided while taking this medicine.

Drug Interactions:

Inform your doctor or pharmacist if you are taking any other medicines which includes over-the-counter drugs, herbal tonics, supplements and medicines that you buy without a prescription. Alert your doctor if you are taking Empraz D 40Mg capsule with clopidogrel, atazanavir, nelfinavir, rilpivirine, rifampicin, azithromycin, clarithromycin, methotrexate, diazepam, verapamil, citalopram, phenytoin, ketoconazole, fluconazole, Posaconazole.

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.