Endobloc T Kit tablet is primarily used for treating pulmonary arterial hypertension (high blood pressure levels in the arteries connecting the heart and lungs) and erectile dysfunction, which is also called impotence, in men. Erectile dysfunction is a condition where a man is unable to achieve or maintain adequate penile erection for sexual intercourse. This happens when there is decreased blood flow to the penis. The decreased blood flow may be due to chronic life style factors such as smoking, drinking or due to physical complications following an injury or diseases such as diabetes, neuropathy, prostate cancer, benign prostatic hyperplasia or due to psychological conditions such as depression, stress, anxiety, etc. This medicine relaxes the smooth muscles present in the wall of blood vessels and helps in increasing blood flow to the penis. However, the uses mentioned are not exhaustive, there may be other conditions for which the medication may be used upon your doctor’s discretion.
The active ingredients of Endobloc T Kit tablet are Ambrisentan (5Mg) and Tadalafil (20Mg)
Tadalafil works by relaxing the smooth muscles present in the walls of blood vessels in the penis. The action of the medicine is limited to particular areas of the body and thus, when there is sexual stimulation, it increases the blood flow in the penis, resulting in improved and successful penile erection. The tablet does not show any effect when there is no sexual stimulation. Ambrisentan is an endothelin receptor blocker that blocks the action of endothelin, a natural substance that causes blood vessels to constrict, causing increase in the pressure in the blood vessels of the lungs. The medicine decreases the blood pressure in pulmonary blood vessels when used to treat pulmonary arterial hypertension.
Patients with following conditions are suggested to seek advice from their healthcare professionals before taking Endobloc T Kit tablet:
The following side effects may or may not occur during the usage of Endobloc T Kit tablet. When taken in the recommended dosage guidelines, the medicine is well tolerated. You may experience one or more of the following common side effects:
Rare but more serious adverse effects may include:
Take Endobloc T Kit tablet as instructed by your doctor. Swallow the tablet whole with water, immediately after opening it from the strip. Do not break or crush or chew the tablet.
Avoid missing or forgetting the dose. If you do, take it as soon as you remember; but if it’s almost time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which is dangerous to your health.
The tablet can be taken with or without food. If significant stomach upset occurs, you could take it with food. Take the tablet at the same time every day as it helps to maintain a consistent level of medicine in the body.
Do not change the dose or stop taking the medicine before completion of the course or without consulting your doctor. Continue to use this drug until completion of the maximum amount suggested.
Avoid taking more than the recommended dosage. In case of accidental overdose, promptly seek medical advice. Depending on the dosage of Endobloc T Kit tablet, symptoms vary in individuals, you may experience one or more of the following symptoms:
Take Endobloc T Kit tablet only on the advice of medical practitioner. Dosage adjustments or complete avoidance of the medication may be required in the following conditions:
Caution is advised among patients with known history of kidney diseases due to increased risk of worsening of the patient’s condition. Dose adjustments of the tablet may be needed. Regular monitoring of kidney function tests is recommended while taking this tablet. If you have any, it is highly recommended that you consult your doctor before taking this medicine.
Extreme caution is advised among people with hepatic problems. Close monitoring of liver function and adjustments of dose of the medicine may be needed based on the clinical condition of the patient. If you have any liver problems, it is highly recommended that you consult doctor before the taking this tablet. However, this medicine is not recommended in patients with severe liver impairment.
Use of Endobloc T Kit tablet is not recommended for use during pregnancy. Studies on human beings and animal have shown adverse effects on the developing baby. It is recommended that you consult your doctor before consuming this medicine.
This medicine is not considered safe to use in nursing mothers unless the potential benefits outweigh the risks involved. Since the effect of the medicine on infants is not clearly established, we recommend that you to consult your doctor before consuming the tablet.
Consumption of alcohol with Endobloc T Kit tablet is not recommended as it increases side effects such as hypotension, flushing, difficulty in concentration, dizziness, persistent headache. Any symptoms of abnormal reactions after taking the medicine should be reported to your doctor immediately.
The tablet may decrease alertness, cause impaired judgement, affect your vision and make you feel dizzy, light headedness, do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.
Grape fruit juice should be avoided.
Inform your doctor or pharmacist if you are taking any other medicines which includes over-the-counter drugs, herbal tonics, supplements and medicines that you buy without a prescription. Alert your doctor if you are taking Endobloc T Kit tablet with itraconazole, angiotensin converting enzyme inhibitors, amlodipine, carbamazepine, nitroglycerin, clarithromycin, dexamethasone, tamsulosin, warfarin, isoniazid, atazanavir, imatinib mesylate, terazosin, rifampicin, leflunomide, tizanidine, deferasirox, lomitapide.
Category X: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
This medication is a phosphodiesterase (PDE) inhibitor, prescribed for erectile dysfunction (impotence; inability to get or keep an erection) in men. It increases blood flow to the penis during sexual stimulation.
Tadalafil helps response to stimulation. It calms lung vessels.
It comes as a tablet to take by mouth (orally), with or without food. Initial: 10 mg once daily at least 30 minutes before sexual activity, up to 20 mgdose. Max: Once daily. If used with potent inhibitors of CYP3A4: Max: 10 mg once every 72 hr.
Flushing. Wearing layers of clothes or summer clothes and staying in cool places may help. Headache. Belly pain or heartburn. Back pain. Nose stuffiness. Eyesight changes may rarely happen.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.
If you have an allergy to tadalafil or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about ras; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you use drugs called poppers like amyl nitrite and butyl nitrite. If you have been told not to have sex by your doctor.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Erection that lasts more than 4 hours. Chest pain or pressure or a fast heartbeat. Very bad dizziness or passing out. Sudden change or loss of eyesight. Change in hearing. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Avoid alcohol and grapefruit juice.
Store at 15-30°C. Store it at room temperature and keep in an airtight container.
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Drugs for Erectile Dysfunction
The tablet is primarily used for treating pulmonary arterial hypertension (high blood pressure levels in the arteries connecting the heart and lungs) and erectile dysfunction, which is also called impotence, in men. Erectile dysfunction is a condition where a man is unable to achieve or maintain adequate penile erection for sexual intercourse. This happens when there is decreased blood flow to the penis. The decreased blood flow may be due to chronic life style factors such as smoking, drinking or due to physical complications following an injury or diseases such as diabetes, neuropathy, prostate cancer, benign prostatic hyperplasia or due to psychological conditions such as depression, stress, anxiety, etc. This medicine relaxes the smooth muscles present in the wall of blood vessels and helps in increasing blood flow to the penis.
The following side effects may or may not occur during the usage of this medicine. When taken in the recommended dosage guidelines, the medicine is well tolerated. More common side effects include unexpected weight gain or loss, runny nose, sore throat, headache, dizziness, bloody or cloudy urine, visual disturbances, painful urination, nasal congestion, nausea, sensitivity to light, flushing, nosebleed, burning, numbness or tingling in the arms and feet, sleeplessness, diarrhea, excessive tearing of the eye. Its use may lead to uncommon side effects such as prolonged and painful erection, deafness, palpitations, urinary tract infections.
The tablet can be taken with or without food or as advised by the doctor. To reduce gastrointestinal discomfort, the medicine may be taken with meals.
If you ever had impaired kidney function, sever liver impairment or heart disease, let your doctor know before taking this medicine. Inform your doctor about all the medicines you take to ensure that you are healthy. This medicine is contraindicated in patients with hypersensitivity to ingredients in the tablet, severe cardiovascular disorders (unstable angina, cardiac failure), hypotension, recent stroke or myocardial infarction, severe hepatic impairment, concomitant use with nitrate containing medicines, pregnancy. Caution is advised among patients with disease of the retina, deformation of penis, priapism, severe renal impairment, loss of vision and hearing, children and lactation women.
The tablet may decrease alertness, cause impaired judgement, affect your vision and make you feel dizzy, light headedness. Do not drive, operate heavy machinery or involve in any works which may demand your attention or physical strength.
The tablet is usually well tolerated when taken in the recommended dosage guidelines. Overdose of this medicine lead to fainting, persistent headache, changes in heart rate, cough with foamy mucus, severe hypotension, prolonged erection, jaundice, dark urine.
The tablet is not recommended for use during pregnancy. Studies on human beings and animal have shown harmful adverse effects on the developing baby. It is recommended that you consult your doctor before consuming this medicine.
No, do not take the tablet without doctor’s prescription.
Consumption of alcohol with this medicine is not recommended as it increases side effects such as hypotension, flushing, difficulty in concentration, dizziness, persistent headache. Any symptoms of abnormal reactions after taking the medicine should be reported to your doctor immediately.
Store the medicine at room temperature (20-30 degree Celsius) in a cool and dry place. Keep the tablet according to the instructions mentioned on the pack or label. Store the medicine in the container or the pack it came in, tightly closed.
This tablet is designed to be swallowed with water. If you take them in a way they weren’t intended to be used, you could experience an overdose if the active constituent enters the blood stream too quickly. Alternatively, if it enters your body too slowly, it may never achieve a high enough concentration to be completely functional.
The safety and efficacy of using this tablet in children has not been established.
The amount of time required for this medicine to show its action in the body is within 30-60 minutes after administration.
The amount of time for which this medicine remains active in the body is clinically not established.
Medicines should always be taken under medical supervision. Take the medicine exactly as prescribed by your doctor: for dosage and duration. Most recommended dose is one tablet a day.
The number of days that any medicine must be taken varies from patient to patient; and case to case. So always stick to your doctor’s suggestion about how many days to take this medicine.
Use the medicine exactly as prescribed by your doctor for the dosage and duration.
Note: All of the above information is for reference purpose only. It is always recommended that you consult a medical professional.
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