ENDOBLOC T KIT TAB

What is Tadalafil for:

This medication is a phosphodiesterase (PDE) inhibitor, prescribed for erectile dysfunction (impotence; inability to get or keep an erection) in men. It increases blood flow to the penis during sexual stimulation.

How does Tadalafil work:

Tadalafil helps response to stimulation. It calms lung vessels.

How should Tadalafil be used:

It comes as a tablet to take by mouth (orally), with or without food. Initial: 10 mg once daily at least 30 minutes before sexual activity, up to 20 mgdose. Max: Once daily. If used with potent inhibitors of CYP3A4: Max: 10 mg once every 72 hr.

Common side effects of Tadalafil :

Flushing. Wearing layers of clothes or summer clothes and staying in cool places may help. Headache. Belly pain or heartburn. Back pain. Nose stuffiness. Eyesight changes may rarely happen.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Tadalafil :

If you have an allergy to tadalafil or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about ras; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you use drugs called poppers like amyl nitrite and butyl nitrite. If you have been told not to have sex by your doctor.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Erection that lasts more than 4 hours. Chest pain or pressure or a fast heartbeat. Very bad dizziness or passing out. Sudden change or loss of eyesight. Change in hearing. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Tadalafil with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid alcohol and grapefruit juice.

How do I store Tadalafil :

Store at 15-30°C. Store it at room temperature and keep in an airtight container.

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Drugs for Erectile Dysfunction

What is Ambrisentan for:

Treating high blood pressure in the lungs (pulmonary arterial hypertension PAH) in certain patients.

How does Ambrisentan work:

Ambrisentan is an endothelin receptor antagonist. It works by blocking a certain substance in the lungs, which helps to decrease blood pressure in the lungs.

How should Ambrisentan be used:

Use ambrisentan as directed by your doctor.
Ambrisentan comes with an extra patient information sheet called a Medication Guide. Read it carefully.
Take ambrisentan by mouth with or without food.
Swallow ambrisentan whole. Do not break, split, crush, or chew before swallowing.
Take ambrisentan on a regular schedule to get the most benefit from it. Taking ambrisentan at the same times each day will help you to remember to take it.
Continue to take ambrisentan even if you feel well. Do not miss any doses

Common side effects of Ambrisentan :

Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Flushing; nose or throat irritation; stuffy nose.
Seek medical attention right away if any of these SEVERE side effects occur:Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); new or worsening shortness of breath; new or worsening swelling of the hands, legs, ankles, and feet; sudden or unusual weight gain; unusual tiredness or weakness.

What do I do if I miss a dose

If you miss a dose of ambrisentan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once

What precautions should I take when taking Ambrisentan :

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are able to become pregnant
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of liver problems, heart failure, or anemia
if you have fluid retention (eg, unusual swelling of the arms, hands, legs, or feet) or a certain lung problem (pulmonary veno-occlusive disease)
if you have had abnormal liver function tests while taking another endothelin receptor antagonist (eg, bosentan)
if you drink alcohol or take medicines that may harm the liver (eg, acetaminophen, methotrexate, ketoconazole, isoniazid, certain medicines for HIV infection). Ask your doctor if you are unsure if any of your medicines might harm the liver
Some men taking another medicine similar to ambrisentan (bosentan) have experienced a decrease in sperm count. A low sperm count may decrease the ability to father a child. It is not known if ambrisentan may cause the same effect on sperm count. Discuss any questions or concerns with your doctor.
Women who are able to become pregnant must have a negative pregnancy test before they start to take ambrisentan, monthly while they are taking it, and for 1 month after they stop taking it. Talk with your doctor for more information.
Women who are able to become pregnant must use 2 effective forms of birth control while they take ambrisentan and for at least 1 month after they stop taking it. Talk with your doctor about the use of effective birth control while you use ambrisentan. Talk with your doctor right away if you miss a menstrual period, have unprotected sex, think your birth control has failed, or think you may be pregnant.
Tell your doctor or dentist that you take ambrisentan before you receive any medical or dental care, emergency care, or surgery.
Lab tests, including liver function, hemoglobin levels, and hematocrit levels, may be performed while you use ambrisentan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use ambrisentan with caution in the ELDERLY; they may be more sensitive to its effects, especially swelling of the arms, hands, legs, or feet.
Ambrisentan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

When do I need to seek medical help

Do NOT use ambrisentan if:
you are allergic to any ingredient in ambrisentan
you are pregnant, may become pregnant, or plan to become pregnant
you have moderate to severe liver problems
you have a certain type of lung problem called idiopathic pulmonary fibrosis
Contact your doctor or health care provider right away if any of these apply to you.
Do NOT take more than the recommended dose without checking with your doctor.
Do not stop taking ambrisentan unless your doctor tells you to.
Serious liver problems have been reported with other medicines that are similar to ambrisentan (eg, bosentan). Contact your doctor right away if you develop symptoms of liver problems, such as nausea, vomiting, loss of appetite, fever, stomach pain, yellowing of the skin or eyes, dark urine, pale stools, itching, or unusual tiredness or achiness. Discuss any questions or concerns with your doctor.

Can I take Ambrisentan with other medicines:

Some medicines may interact with ambrisentan. Tell your health care provider if you are taking any other medicines, especially any of the following:
Cyclosporine because it may increase the risk of ambrisentan's side effects.

How do I store Ambrisentan :

Store ambrisentan between 20 and 25 degrees C in the original package. Store away from heat, moisture, and light. Do not store in the bathroom. Keep ambrisentan out of the reach of children and away from pets.

Pregnancy Category

Pregnancy Category:X
Do not take ambrisentan if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking ambrisentan.

Therapeutic Classification

Other Drugs Acting on the Respiratory system, Other Cardiovascular Drugs