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Flexone D Tablet
Uses and Benefits

Uses and Benefits

Flexone D Tablet is a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic properties used in the treatment of acute and chronic signs and symptoms of osteoarthritis and rheumatoid arthritis. Besides, it is used as a muscle relaxant as well. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.



The active ingredients of Flexone D Tablet are Metaxolone 400mg and Diclofenac 50mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Metaxalone is a muscle relaxant that works by blocking the nerve impulses to the brain that carry pain sensation. Thereby helps in reducing the sensation of pain and injury in the body.

Diclofenac acts by inhibiting the prostaglandin synthesis. Prostaglandins are basically compounds that get produced in huge numbers, as a response to pain, injury or infection. The large production of prostaglandins causes inflammation associated with redness, swelling, pain and fever. Thus by inhibiting their synthesis, Diclofenac treats inflammation and reduces pain.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before taking Flexone D Tablet:

  • Hypersensitivity to any of the ingredient used in the Flexone D Tablet such as Metaxalone and Diclofenac
  • ASA or NSAID induced asthma or urticaria
  • Aspirin traid
  • CABG surgery periop use
  • Anemia
  • Significant renal impairment
  • Significant hepatic impairment
  • Caution:
  • Renal impairment
  • Hepatic impairment
  • Asthma
  • Cardiovascular disease
  • Cardiac disease risk
  • HTN
  • CHF
  • Fluid retention
  • Coagulation disorder
  • GI Bleeding or ulcer
  • Prolonged use
  • Smoker
  • Elderly patients
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Flexone D Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Dyspepsia
  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Constipation
  • Flatulence
  • Headache
  • Dizziness
  • Rash
  • Pruritus
  • Urtcaria
  • Drowsiness
  • Fluid retention
  • Peripheral edema
  • Tinnitus
  • Sinusitis photosensitivity
  • Delayed ovulation
  • Drowsiness
  • Nervousness
  • Dyspepsia

Rare but more serious adverse effects may include:

  • GI bleeding
  • GI perforation
  • Ulcer
  • Stroke
  • Thromboembolism
  • HTN
  • CHF
  • Renal papillary necrosis
  • Nephrotoxicity
  • Hepatotoxicity
  • Pancreatitis
  • Anaphylactoid reaction
  • Bronchospasm
  • Exfoliative dermatitis
  • Steven-Johnson syndrome
  • Erythema multiforme
  • Anemia
  • Blood dyscrasias
  • Prolonged bleeding time
  • Hyperkalemia
  • Anemia, haemolytic
  • Leukopenia
  • Anaphylaxis
  • Hypersensitivity reaction
  • Jaundice
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow Flexone D Tablet whole immediately after opening it from the strip. Do not break/cut/chew the tablet.
Avoid missing a dose. If you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Do not swallow two doses at the same time which may be dangerous to your health.
Take the Flexone D Tablet either with or without food.
For adults: Do not exceed more than 3 doses in a day or take it as directed by your physician or pharmacist.
For children: talk to your doctor before giving the tablet.


Avoid using more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Lethargy
  • Tinnitus
  • Headache
  • Drowsiness
  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Disorientation
  • Excitation
  • Epigastric pain
  • Anaphylactoid reactions
  • Fits
  • Coma
  • Acute renal failure
  • Vertigo
  • Lethargy
  • Agitation
  • Slurred speech
  • Tremor
  • Tachycardia
Warnings and Precautions

Warnings and Precautions

Take the tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:


To make sure Diclofenac is safe for you, inform your doctor if you have any renal problems (before consumption of this medicine).


To make sure Diclofenac is safe for you, inform your doctor if you have any hepatic problems (before consumption of this medicine).


Safety during pregnancy is unknown. Therefore, inform your doctor if you are pregnant or planning to become pregnant (before consumption of this medicine).


Safety during lactation is unknown. Therefore, inform your doctor if you are a nursing mother (before consumption of this medicine).

Drug Interactions:

Caution always advised when used along with other medicines especially inform your doctor if you start or stop using medicine(s) such as cyclosporin, lithium, methotrexate, rifampin, antifungal medicines, blood thinners, Heart or blood pressure-related medicines, NSAIDs, steroids and any other forms of Diclofenac, etc.

  • Keep the medicine out of sight and reach of children.
  • Keep it in a hygienic and cool place away from heat and moisture.
  • Do not use the medicine beyond its expiry.
FDA Pregnancy Category

FDA Pregnancy Category

Category N: No information available.

Drug Composition information
What is Diclofenac for:

This medication is an NSAID, prescribed for severe pain. This medication decreases the hormones that cause inflammation and pain in the body.

How does Diclofenac work:

Diclofenac blocks chemicals that cause pain and swelling.

How should Diclofenac be used:

PO- The recommended dosage is 100-200 mgday in divided doses.Topical- Apply the gel (4 g) to the affected area, 4 times daily. It comes as a tablet to take by mouth, with food.It also comes as a gel to apply topically.

Common side effects of Diclofenac :

Headache. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative. Loose stools (diarrhea). Harm to the liver may rarely happen.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Many times this drug is taken on an as needed basis

What precautions should I take when taking Diclofenac :

If you have an allergy to diclofenac or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are more than 24 weeks pregnant.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Chest pain or pressure. Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight. Very upset stomach or throwing up. Very bad belly pain. Very bad swelling or pain of hands or feet. A big weight gain. Black, tarry, or bloody stools. Blood in the urine. Very loose stools (diarrhea). Not able to eat. Any bruising or bleeding. Yellow skin or eyes. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Diclofenac with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Diclofenac :

Store it at room temperature and in an airtight container. Keep away from excess heat and moisture.

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) , Non-Opioid Analgesics & Antipyretics

Seller Information
Manufactured By


plot no 178/ eastern street no 14, surya nagar,hyderabad - 500039 india

Packed By


plot no 178/ eastern street no 14, surya nagar,hyderabad - 500039 india

Applicable Offers

  • 20% Discount
    On prescription medicines, orders above Rs 1000 T & C
  • 10% Discount
    On prescription medicines, orders above Rs 200 T & C

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