This medication contains sulfonylurea and biguanide antidiabetic combination, prescribed for type 2 diabetes.
Glyburide raises insulin levels and helps tissues respond better to the insulin. Metformin lowers sugar and helps insulin work better.
It comes as a tablet to take by mouth, with food. Adult: PO- Per tab contains glibenclamide 1.25 mg and metformin 250 mg. As initial therapy: Start with 1 tab 1-2 timesday. It may be increased if needed.
Low blood sugar. Signs include anger, shaking, a fast heartbeat, confusion, or sweating. Keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Headache. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Bad taste in your mouth. This most often goes back to normal. Too much acid in the blood (lactic acidosis) may rarely happen.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses
If you have an allergy to glyburide, metformin, or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have a sulfa (sulfonamide) allergy, talk with your doctor. If you have any of these health problems: Acidic blood problem, drink too much alcohol, fluid loss, kidney disease, or liver disease. If you are having an x-ray with dye.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very low blood sugar or very high blood sugar. Trouble breathing. Very bad dizziness. Very upset stomach or throwing up. Very loose stools (diarrhea). Very bad muscle pain or weakness. Feeling cold. Feeling very tired or weak. Dark urine or yellow skin or eyes. Very bad belly pain. Not able to eat. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
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