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    • Madol MR Tablet
      Uses and Benefits

      Uses and Benefits

      Madol MR Tablet is used to treat moderate to severe pain and inflammation in adults.It is also used to treat painful muscle spasm associated with musculoskeletal conditions. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon a doctor’s discretion.

      Composition

      Composition

      The active ingredient of Madol MR Tablet are Chlorzoxazone 250mg, Diclofenac 50mg, and Tramadol 37.5mg.

      Mechanism of Action of Drugs

      Mechanism of Action of Drugs

      Chlorzoxazone reduces skeletal muscle spasm and relieves one from pain.

      Diclofenac acts by inhibiting the prostaglandin synthesis. Prostaglandins are basically compounds that get produced in huge numbers, as a response to pain, injury or infection. The large production of prostaglandins causes inflammation associated with redness, swelling, pain and fever. Thus by inhibiting their synthesis, Diclofenac treats inflammation and reduces pain.

      Tramadol acts by withholding the chemical neurotransmitters which enhance pain. Simultaneously, this drug also enhances the serotonin release which contributes to happiness and well-being by calming and relaxing the mind.

      Contraindications and Cautions

      Contraindications and Caution

      Patients with the following conditions are suggested to seek advice from their health care professionals before taking the Madol MR Tablet:

      • Hypersensitivity to any of the ingredients used in the Madol MR Tablet such as Chlorzoxazone, Diclofenac, and Tramadol and Opioids
      • AsA or Nsaid induced asthma or urticaria
      • Aspirin traid
      • Pregnancy starting at 30 week gestation
      • MAO inhibitor use within 14dyas
      • Ultrarapid CYP26 metabolizer
      • Patients with 12-18 years old with respiratory depression risk
      • Post tonsillectomy or adenoidectomy
      • Respiratory depression, severe
      • Asthma, acute or severe
      • GI obstruction, known or suspected
      • Paralytic ileus
      • Acute alcohol or drug intoxication
      • Suicidal ideation or behavior
      • Circulatory shock
      • Coma or impaired consciousness
      • Electrolyte abnormalities, uncorrected
      • Severe hepatic impairment (ER form)
      • Severe renal impairment (ER form)
      • Avoid abrupt withdrawal (prolonged or longterm use)
      • Caution:
      • Pulmonary impairment
      • Severe renal impairment (IR form)
      • Severe hepatic impairment
      • Seizure history
      • Seizure risk
      • Head injury
      • Sleep apnea
      • CNS depression
      • Concurrent CNS depressant use
      • Alcohol use
      • Mental illness history
      • Psychiatric disorder
      • Hypovolemia
      • Acute pancreatitis or biliary disease
      • GU obstruction
      • Congenital long QT syndrome
      • QT prolongation
      • QT prolongation family history
      • Torsades depointed history
      • Ventricular arrhythmias
      • Bradycardia
      • Recent MI
      • CHF
      • Caution in patients trying to conceive
      • HTN
      • Fluid retension
      • Coaggulation disorder
      • GI bleeding or ulcer history
      Side Effects

      Side and Adverse Effects

      The following side effects may or may not occur during the usage of this Madol MR Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

      • Dizziness
      • Nausea
      • Constipation
      • Headache
      • Somnolence
      • Vomiting
      • Pruritus
      • CNS stimulation
      • Asthenia
      • Diaphoresis
      • Dyspepsia
      • Xerostomia
      • Diarrhea
      • Flushing
      • Anorexia
      • Insomnia
      • Urticaria
      • Peripheral edema
      • Tinnitus
      • Ecchymosis
      • Sinusitis
      • Photosensitivity
      • Delayed ovulation
      • Malaise
      • Over stimulation
      • Anorexia
      • Vomiting
      • Heart burn
      • Abdominal distress
      • Diarrhea
      • Hepatic jaundice
      • Urine discolouration
      • Rashes
      • Petechiae
      • Ecchymosis

      Rare but more serious adverse effects may include:

      • Seizures
      • Serotonin syndrome
      • Respiratory depression
      • Central sleep apnea
      • Anaphylaxis
      • Hypersensitivity reaction
      • Stevens-johnson syndrome
      • Toxic epidermal necrolysis
      • Hypotension, orthostatic
      • Syncope
      • Adrenal insufficiency
      • Biliary syndrome
      • Paralytic ileus
      • QT prolongation
      • Suicidal ideation
      • Dependency abuse
      • Opioid-induced androgen deficiency (long term use)
      • GI bleeding
      • GI perforation/ulcer
      • Stroke
      • Thromboembolism
      • Renal papillary necrosis
      • Nephrotoxicity
      • Hepatotoxicity
      • Hepatic necrosis
      • Pancreatitis
      • Anaphylactoid reaction
      • Prolonged bleeding time
      • Headache
      • Exacerbation
      • Hyperkalemia
      • Erythema multiforme
      • Hepatocellular toxicity
      How to Use

      How to Use

      Do not exceed the dose prescribed by your doctor.
      Swallow Madol MR Tablet immediately after opening it from the strip. Do not break or chew the Madol MR Tablet.
      Avoid missing/forgetting a dose. If you do, take it as soon as you remember; but if it is almost time for your next dose, skip it and take it according to your normal schedule. Don’t consume two doses at the same time which may be dangerous to your health.
      Take Madol MR Tablet with or without food.
      Take the medication at the prescribed time and dosage.

      Overdosage

      Avoid taking Madol MR Tablet more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

      • Miosis
      • Vomiting
      • Cold and clammy skin
      • Respiratory depression
      • Lethargy
      • Flaccid skeletal muscle
      • Coma
      • Seizures
      • Brady cardia
      • Hypotension
      • Cardiac arrest
      • Cardiac collapse
      • Malaise
      • Sluggishness
      • Loss of muscle tone
      • Decreased or absent deep tendon reflexes
      • Hypotension
      • Respiratory depression
      Warnings and Precautions

      Warnings and Precautions

      Take Madol MR Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

      Kidney:

      Caution advised among people with renal problems. If you have any, consult your doctor before the consumption of this Madol MR Tablet.

      Liver:

      Caution advised among people with hepatic problems. If you have any, consult your doctor before the consumption of this Madol MR Tablet.

      Pregnancy:

      Safety during pregnancy has not yet established and the risk of teratogenicity is expected (chances are low). Therefore, inform your doctor about if you are pregnant or planning to become pregnant during the treatment.

      Lactation:

      Caution advised during pregnancy. Therefore, inform your doctor if you are a nursing mother during the treatment.

      Driving:

      Since consuming this medicine would induce sleep/cause dizziness or impair your thinking or reactions, do not drive, operate heavy machinery or involve in any works which may demand your attention/physical strength

      Drug Interactions:

      Caution always advised when used with other medicine(s). Therefore, inform your doctor about your previous and current history of medication(s) (if any).

      Precautions
      • Keep the medicine out of sight and reach of children.
      • Store at room temperature, protect from heat and moisture.
      • Do not use the Madol MR Tablet beyond its expiry.
      FDA Pregnancy Category

      FDA Pregnancy Category

      Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


      Drug Composition information
      What is Chlorzoxazone for:

      This medication is a muscle relaxant, prescribed for muscle spasm and the resulting pain or discomfort. It is used in combination with physical therapy, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (such as aspirin or acetaminophen), and rest.

      How does Chlorzoxazone work:

      Chlorzoxazone works in the brain to ease pain.

      How should Chlorzoxazone be used:

      Oral: The recommended initial dose is 500 mg 3-4 timesday. May reduce to 250 mg 3-4 timesday subsequently. Max: 750 mg 3-4 timesday. It comes as a tablet to take by mouth. It usually is taken three or four times a day with food.

      Common side effects of Chlorzoxazone :

      Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

      What do I do if I miss a dose

      Take a missed dose as soon as you think about it. - If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. - Many times this drug is taken on an as needed basis.

      What precautions should I take when taking Chlorzoxazone :

      If you have an allergy to chlorzoxazone or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have liver disease. If you are breast-feeding.

      When do I need to seek medical help

      If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of low potassium. Very bad dizziness or passing out. Very upset stomach or throwing up. Not able to pass urine. Any rash. Side effect or health problem is not better or you are feeling worse.

      Can I take Chlorzoxazone with other medicines:

      Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

      Are there any food restrictions

      Avoid Alcohol

      How do I store Chlorzoxazone :

      Oral: Store at 15-30°C. Store it in air tight container and keep away from children.

      Pregnancy Category

      Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

      Therapeutic Classification

      Muscle Relaxants

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