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    • Madol PD Tablet
      Uses and Benefits

      Uses and Benefits

      Madol PD Tablet is most commonly prescribed to treat fever, mild to moderate pains such as muscleaches, headache, toothache, arthritis, backache, menstrual cramps, and post-immunization pyrexia. Besides, it is also used to treat nausea and vomiting, gastroinstestinal motolity disorders, etc. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.

      Composition

      Composition

      The active ingredients of Madol PD Tablet are Domperidone 10mg, Paracetamol (also known as Acetaminophen) 325mg and Tramadol 50mg.

      Mechanism of Action of Drugs

      Mechanism of Action of Drugs

      Domperidone possesses anti-emetic properties which help reduce vomiting and vomiting sensation; and also treats gastric problems to an extent.

      Paracetamol (or Acetaminophen) primarily acts as an analgesic and an antipyretic agent. It also possesses anti-inflammatory properties. It produces its analgesic effects by increasing the pain threshold and antipyresis by acting on the hypothalamic heat-regulating center.

      Tramadol acts by withholding the chemical neurotransmitters which enhance pain. Simultaneously, this drug also enhances the serotonin release which contributes to happiness and well-being by calming and relaxing the mind.

      Contraindications and Cautions

      Contraindications and Caution

      Patients with the following conditions are suggested to seek advice from their health care professionals before taking the Madol PD Tablet:

      • Hypersensitivity to any of the components used in the Madol PD Tablet such as Domperidone, Paracetamol (Acetaminophen) and Tramadol
      • Hypersensitivity to opioids
      • MAO inhibitor use within 14 days
      • Respiratory depression risk (12-18 years old)
      • Post-tonsillectomy or adenoidectomy use (< 18 years old)
      • Respiratory depression, severe
      • Asthma, acute or severe
      • GI obstruction, known or suspected
      • Paralytic ileus
      • Acute alcohol or drug intoxication
      • Suicidal ideation or behavior
      • Circulatory shock
      • Coma or impaired consciousness
      • Electrolyte abnormalities
      • Hepatic impairment, severe
      • Renal impairment, severe
      • Prolatin realeasing pitutary tumor
      • QT prolongation
      • Electrolyte disturbance
      • Cardiac disease
      • GI haemorrhage
      • Caution:
      • Hepatic impairment
      • Malnutrition
      • Hypovolemia
      • Chronic alcohol use
      • Pulmonary impairment
      • Head injury
      • Sleep apnea
      • Concurrent CNS depressant use
      • Alcohol use
      • History of mental illness
      • Psychiatric disorder
      • Hypovolemia
      • Acute pancreatitis or biliary disease
      • Congenital long QT syndrome
      • QT prolongation
      • QT prolongation family history
      • Ventricular arrhythmias
      • Bradycardia
      • Recent MI
      • CHF
      • Trying to conceive (Long-term use)
      Side Effects

      Side and Adverse Effects

      The following side effects may or may not occur during the usage of Madol PD Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

      • Nausea
      • Skin rash
      • Tinnitus
      • Dryness of mouth
      • Decreased appetite
      • Mouth ulcer
      • Gastric problems
      • Palpitation
      • Dizziness
      • Abdominal discomfort
      • Constipation
      • CNS stimulation
      • Asthenia
      • Dyspepsia
      • Flushing
      • Anorexia
      • Insomnia
      • Pruritus
      • Xerostomia
      • Increased prlactin levels
      • Convulsions
      • Dystonic reactions
      • Transient intestinal cramps
      • Nervousness
      • Anxiety
      • Asthenia
      • Agitation

      Rare but more serious adverse effects may include:

      • Thrombocytopenia
      • Hypokalemia
      • Anemia
      • Hepatotoxicity
      • Anaphylaxis
      • Renal tubular necrosis, acute
      • Seizures
      • Serotonin syndrome
      • Respiratory depression
      • Hypersensitivity reaction
      • Anaphylactoid reaction
      • Stevens-johnson syndrome
      • QT prolongation
      • Dependency, abuse
      • Serious ventricular arrhythmia
      • Sudden cardiac death
      • Torsade depointes
      • Anaphylaxis angioedema
      How to Use

      How to Use

      Do not exceed the dose prescribed by your doctor. Swallow the Madol PD Tablet immediately after opening it from the strip. Do not break/crush/chew the Madol PD Tablet.

      Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Don’t swallow two doses at the same time which may be dangerous to your health.

      Take Madol PD Tablet with or without food.
      Take the medication at the prescribed time and dosage.
      For children: talk to your doctor before giving the Madol PD Tablet.

      Overdosage

      Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

      • Abdominal pain
      • Yellow skin
      • Blood clotting
      • Confusion
      • Hypoglycemia
      • Lactic acidosis
      • Convulsions
      • Agitation
      • Didorientation
      Warnings and Precautions

      Warnings and Precautions

      Take the Madol PD Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

      Kidney:

      Caution advised among people with renal problems. If you have any, consult your doctor before the consumption of this Madol PD Tablet.

      Liver:

      Caution advised among people with hepatic problems. If you have any, consult your doctor before the consumption of this Madol PD Tablet.

      Pregnancy:

      Domperidone: Safety during pregnancy is uknown.
      Paracetamol: This medicine may be used during pregnancy – no known risk of fetal harm. However, consider taking the Madol PD Tablet only if suggested by a doctor.

      Tramadol: Do not take this drug if you are pregnant or planning to become pregnant because consumption of this drug may lead to life-threatening withdrawal symptoms in new-born.

      Lactation:

      Domeperidone: Safety during lactation is uknown.
      Paracetamol: This medicine may be used while breastfeeding – no known risk of infant harm based on human data. However, no human studies are available to estimate effects on milk production.

      Tramadol: Do not take this drug if you are breastfeeding a baby because this drug may pass into breast milk and may harm a breastfeeding infant.

      Alcohol:

      Do not take Madol PD Tablet along with alcohol as this may increase your hepatic problems.

      Driving:

      Since consuming this medicine would induce sleep/cause dizziness or impair your thinking or reactions, do not drive, operate heavy machinery or involve in any works which may demand your attention/physical strength.

      Drug Interactions:

      Caution always advised when used with other drugs especially drugs that make you sleepy, slow your breathing, sleeping pill, muscle relaxer, sedative tranquilizer or antipsychotic medicine and drugs that affect serotonin levels in your body, etc.

      Precautions
      • Keep the Madol PD Tablet out of sight and reach of children.
      • Store the medicine in room temperature away from heat and moisture.
      • Do not use the Madol PD Tablet beyond its expiry.
      • Do not use the tablet with other forms of paracetamol-containing medications.
      FDA Pregnancy Category

      FDA Pregnancy Category

      Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


      Drug Composition information
      What is Domperidone for:

      This medication is an antidopaminergic agent, used in treating nausea, vomiting, gastrointestinal problems and Parkinson’s disease.

      How does Domperidone work:

      Domperidone helps the stomach get rid of food and lowers signs of an upset stomach, throwing up, heartburn, and fullness.

      How should Domperidone be used:

      Adult: Oral- Nausea and vomiting- 10-20 mg 4-8 hourly. Max: 80 mgday. Non ulcer dyspepsia- 10-20 mg 3 timesday and at night. Migraine- 20 mg 4 hourly. Max: 4 doses24 hour. Rectal- Nausea and vomiting- 60 mg twice daily. It is available in various forms like tablet, drop, suspension, capsule to take by mouth, on an empty stomach.

      Common side effects of Domperidone :

      Headache. Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often

      What do I do if I miss a dose

      Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

      What precautions should I take when taking Domperidone :

      Alert your doctor if you have stomach problems (such as stomach bleeding or intestinal blockage) or prolactinoma (a tumour that releases a hormone called prolactin). - Alert your doctor if you have heart, liver or kidney disease, or if you have breast cancer. - Alert your doctor if you are pregnant or breastfeeding. Do not breastfeed while being treated with Domperidone.

      When do I need to seek medical help

      If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. A fast heartbeat. Very bad dizziness or passing out. Seizures. Any rash. Side effect or health problem is not better or you are feeling worse.

      Can I take Domperidone with other medicines:

      Alert your doctor quickly if you are taking any of the following medications: - bromocriptine - heart medicines, especially those used to control irregular heartbeat. - antidepressants known as MAOI, such as phenelzine, isocarboxazid. - other mood medicines such as mesoridazine, thioridazine. - painkillers such as codeine, morphine. - Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

      Are there any food restrictions

      Avoid Alcohol

      How do I store Domperidone :

      Oral: Store it at controlled room temperature (15-30°C).

      Pregnancy Category

      Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

      Therapeutic Classification

      Antiemetics, GIT Regulators & Anti-Inflammatories

      Seller Information
      Manufactured By

      XIEON LIFE SCIENCES PVT LTD

      h.o 171, sec - 3, hsiidc industrial area, sector 3, karnal, haryana 132001

      Packed By

      XIEON LIFE SCIENCES PVT LTD

      h.o 171, sec - 3, hsiidc industrial area, sector 3, karnal, haryana 132001

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