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Country of origin: INDIA

10 Units/pack

MRP 110.60

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Metrogyl Compound Plus Tablet
Uses and Benefits

Uses and Benefits

Metrogyl Compound Plus tablet is a combination of 3 drugs. The medicine is used to treat asymptomatic intestinal amebiases such as loose stools, abdominal cramping, and stomach pain. This tablet also helps to treat certain infections caused by protozoa and certain strains of anaerobic bacteria and also relieves from painful pressure caused by excess gas in the stomach and intestines. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctor’s discretion.



The active ingredients of Metrogyl Compound Plus Tablet are Diloxanide Furoate 375mg, Ornidazole 250mg, and Simethicone 25mg.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

The exact mechanism of action of Diloxanide Furoate is unknown but it is believed to be that this drug may inhibit the protein synthesis of bacteria or a parasite.

Ornidazole is a 5 nitroimidazole derivative which acts by the destruction of helical DNA structure, inhibition of protein synthesis and cell death in the susceptible bacteria.

Simethicone works by reducing the surface tension of gas bubbles, therefore, spread and arrest gas pockets In the gastrointestinal tract.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before using the metrogyl Compound Plus Tablet:

  • Hypersensitivity to any of the components used in the tablet such as Diloxanide Furoate, Ornidazole or other nitroimidazole derivatives, and Simethicone
  • Intestinal perforation
  • GI Obstruction
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Metrogyl Compound Plus Tablet. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Nausea
  • Vomiting
  • Dizziness
  • Tremor
  • Rigidity
  • Tremor
  • Poor coordination
  • Seizures
  • Tiredness
  • Vertigo
  • Temporary loss of consciousness
  • Taste disturbances
  • Skin reactions
  • Diarrhea
How to Use

How to Use

Do not exceed the dose prescribed by your doctor. Swallow Metrogyl Compound Plus Tablet whole, immediately after opening the tablet from the strip.
Do not break/cut/chew the tablet. If you forget your dose take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Do not swallow two doses at the same time which is dangerous to your health.
Take the tablet with or without food, Preferably after food to minimize the gastric problems.
Dosage as recommended by your doctor or follow the instructions given on the prescription.


Avoid taking more than the prescribed dosage. In case of an accidental overdose, look for any new symptoms. If you observe any, promptly seek medical advice or report it to the nearby poison control center.

Warnings and Precautions

Warnings and Precautions

Take Metrogyl Compound Plus Tablet only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:


Do not take this tablet without informing your doctor if you are pregnant or planning to become pregnant.


Do not take this medicine without informing your doctor if you are a nursing mother because it is not known whether this drug may pass into mothers milk or it could harm a breastfed infant.

Drug Interactions:

Caution always advised when used with other medicines such as OTC medicines, herbal supplements or vitamin medicines, tell your doctor if you use any Coumarin type oral anti-coagulants, vecuronium bromide etc.

  • Keep the medicine out of sight and reach of children.
  • Store at room temperature away from heat and moisture.
  • Do not use the medicine beyond its expiry.
FDA Pregnancy Category

FDA Pregnancy Category

Category N: No information available.

Drug Composition information
What is Diloxanide Furoate for:

This medication is an anti-protozoal agent.

How does Diloxanide Furoate work:

This drug is prescribed for intestinal amoebiasis.

How should Diloxanide Furoate be used:

Adult: PO- The recommended dose is 500 mg 3 timesday for 10 days. May repeat course if needed. It comes as a tablet to take by mouth, with food.

Common side effects of Diloxanide Furoate :

Flatulence, loss of appetite, nausea, vomiting, itching and hives.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Diloxanide Furoate :

Caution needed for pregnant and breastfeeding women.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Trouble breathing. Very bad dizziness or passing out. Very upset stomach or throwing up. Sudden change in eyesight, eye pain, or irritation. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Diloxanide Furoate with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Diloxanide Furoate :

Store away from heat and direct light.

Pregnancy Category

Category N : Not yet classified.

Therapeutic Classification


Applicable Offers

  • 20% Discount
    On prescription medicines, orders above Rs 1000 T & C
  • 10% Discount
    On prescription medicines, orders above Rs 200 T & C
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