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MRP 43.73

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NOR METROGYL O 60ML SYP

Nor Metrogyl O Syrup 60ml
Uses and Benefits

Uses and Benefits

Nor Metrogyl O Syrup 60ml is an antibiotic medication helps to fight against certain bacterial and parasitic infections in the body such as trichomoniasis, giardiasis, acute intestinal amebiasis (amebic dysentery), anaerobic bacterial infection, antibiotic-associated pseudomembranous colitis, and in helicobacter pylori eradication therapy. This medicine also used in dental, joints, and skin, lungs, prostate or urinary tract infections. However, the uses mentioned here are not exhaustive. There may be other conditions for which this medication may be used upon doctors discretion.

Composition

Composition

The active ingredients of Nor Metrogyl O Syrup 60ml are Metronidazole 100mg and Ofloxacin 50mg/5ml.

Mechanism of Action of Drugs

Mechanism of Action of Drugs

Metronidazole is a biologically inactive compound which can be metabolized in the body (prodrug) to produce its effect. This acts by withholding the bacterial nucleic acid synthesis and helps in the ramification of bacterial cell death.

Ofloxacin is a fluoroquinolone which acts by showing bactericidal activity against a wide range of gram negative and gram positive microorganisms and also restrain bacterial topoisomerase IV and DNA gyrase enzymes.

Contraindications and Cautions

Contraindications and Caution

Patients with the following conditions are suggested to seek advice from their health care professionals before using this Nor Metrogyl O Syrup 60ml:

  • Hypersensitivity to any of the ingredients used in the Nor Metrogyl O Syrup 60ml such as Metronidazole and Ofloxacin
  • Disulfiram use within any 14 days
  • Myasthenia gravis
  • Aromatic aneurysm
  • Aromatic Dissection
  • Caution:
  • Cockayne syndrome
  • CNS disorder
  • Blood dyscrasia
  • Hepatic impairment
  • Congenital long QT Syndrome
  • Ventricular arrhythmias
  • Bradycardia
  • Recent MI
  • CHF
  • Kidney or heart or lung transplant
  • Renal impairment
  • Hepatic impairment
  • Seizure disorde
  • CNS Disorder
  • Diabetes mellitus
Side Effects

Side and Adverse Effects

The following side effects may or may not occur during the usage of Nor Metrogyl O Syrup 60ml. It is generally well tolerated when taken in the prescribed dosage guidelines. More common ones are generally mild and may include:

  • Nausea
  • Vomiting
  • Epigastric discomfort
  • Abdominal cramps
  • Diarrhea
  • Headache
  • Dizziness
  • Dark red-brown urine
  • Candidiasis
  • Abnormal ECG
  • Dyspepsia
  • Restlessness
  • Vaginitis
  • Insomnia
  • Photosensitivity
  • Pruritis
  • Rash
  • Agitation
  • Confusion
  • Disorientation
  • Impaired memory
  • Tremor
  • Nightmares
  • Hyperglycemia
  • Paranoia
  • Attention disturbance

Rare but more serious adverse effects may include:

  • Seizures
  • Aseptic meningitis
  • Peripheral neuropathy
  • Optic neuropathy
  • Encephalopathy
  • Stevens-johnson syndrome
  • Leukopenia
  • Thrombocytopenia
  • Carcinogenicity
  • Pancreatitis
  • Anaphylaxis
  • Phototoxicity
  • Superinfection
  • Toxic Psychosis
  • Suicidality
  • Depression
  • Vasculitis
  • Serum sickness
  • Peripheral neuropathy
  • Hepatotoxicity
  • Nephrotoxicity
  • Crystalluria
  • QT prolongation
  • Torsades de pointes
  • Tendon rupture
  • Arthropathy
  • Myasthenia gravis exacerbation
  • Hypoglycemia (Severe)
  • Aortic aneurysm
  • Aortic dissection
How to Use

How to Use

Do not exceed the dose prescribed by the doctor. Nor Metrogyl O Syrup 60ml is meant for oral administration. Shake the bottle well before using. Dosage can be administered with the cap that comes along with the container.
Avoid missing or forgetting a dose. If you do, take it as soon as you remember; but if it is time for your next dose, skip it and take it according to your normal schedule. Do not consume two doses at the same time which is dangerous to your health.
Take Nor Metrogyl O Syrup 60ml with or without food, preferably after food.
Dosage as suggested by your doctor or follow the instructions given on the prescription.

Overdosage

Avoid taking more than the prescribed dosage. In case of an accidental overdose, promptly seek medical advice. Depending on the dosage, symptoms may vary but you may experience one or more of the following signs or symptoms:

  • Vomiting
  • Ataxia
  • Slight disorientation
  • Confusion
  • Dizziness
  • Impairment of Consciousness
  • Convulsive seizures
  • GI Reactions
Warnings and Precautions

Warnings and Precautions

Take Nor Metrogyl O Syrup 60ml only on the advice of a medical practitioner. Dosage adjustment or complete avoidance of the medication may be required in the following conditions:

Liver:

Inform your doctor if you have any hepatic problems because this may get metabolized in the liver.

Pregnancy:

Metronidazole: Caution advised during pregnancy. This drug is not recommended during the 1st trimester of pregnancy. Hence, inform your doctor once before taking the Nor Metrogyl O Syrup 60ml.
Ofloxacin: Inform your doctor before taking this drug if you are pregnant or planning to become pregnant because no data available whether this drug may harm an infant or not.

Lactation:

Metronidazole: Caution advised during lactation; possible risk of infant diarrhea and oral thrush based upon the limited human data and no human data available to evaluate effects on the milk production.
Ofloxacin: Do not breastfeed your infant if you take this drug because this drug may pass into breast milk and harm a breastfed infant.

Alcohol:

Do not take alcohol at least for 3 days after taking this Nor Metrogyl O Syrup 60ml because this may lead to unpleasant side effects such as tachycardia, warmth or redness under the skin, tingling sensation, nausea, and vomiting.

Drug Interactions:

Caution always advised when used with other medicines such as over the counter medicines, herbal supplements, and vitamins supplements such as aluminum, calcium, iron magnesium and zinc and also with other drugs such as cimetidine, antiepileptics, anticoagulants, lithium, disulfiram, calcium, magnesium, aluminum, sucralfate, didanosine powder.

Precautions
  • Keep Nor Metrogyl O Syrup 60ml out of sight and reach of children.
  • Store in a cool and hygienic place, away from heat and moisture.
  • Do not use the Nor Metrogyl O Syrup 60ml beyond its expiry date.
  • Do not use Nor Metrogyl O Syrup 60ml if the cap seal is broken before its use and if any particles are floating in the liquid.
FDA Pregnancy Category

FDA Pregnancy Category

Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Drug Composition information
What is Metronidazole for:

This medication is an antibacterial agent, prescribed for trichomoniasis, amebiasis and other bacterial infections. It fights against bacteria in the body.

How does Metronidazole work:

It is used to treat dental, brain, lung, skin, vagina, bone, joint, digestive tract and blood infections.

How should Metronidazole be used:

Use Metronidazole exactly as directed by your doctor. Do not use more or less than instructed by your doctor.

Common side effects of Metronidazole :

Metronidazole may cause diarrhoea, nausea, loss of appetite, metallic taste in the mouth, constipation and dark or tea-coloured urine. These side effects are usually temporary. If you have diarrhoea, drink lots of water to replace the fluids lost. However, if you have severe diarrhoea or diarrhoea with severe stomach cramps or bloody stools, alert your doctor.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Metronidazole :

Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat

Can I take Metronidazole with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

Avoid Alcohol

How do I store Metronidazole :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Other Antibiotics, Antiamoebics, Preparations for Vaginal Conditions

Applicable Offers

  • 20% Discount
    On prescription medicines, orders above Rs 1000 T & C
  • 10% Discount
    On prescription medicines, orders above Rs 200 T & C

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