This medication is a selective and irreversible monoamine oxidase inhibitor (MAOI), prescribed for Parkinson’s disease either alone or with levodopa as an adjuvant. It prevents the breakdown of dopamine in the brain, thus improving the symptoms of Parkinson’s disease.
Selegiline helps keep chemical balance in the brain. With low mood (depression), sleep and eating habits may get better fast. Other signs may take up to 4 to 6 weeks to get better.
It comes as a capsule and tablet to take by mouth. The recommended dose is 10 mgday in single or divided doses. Oral disintegrating tablets are taken at a dose of 1.25 to 2.5 mg placed under the tongue.
Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you. Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Headache. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Not able to sleep. Skin irritation.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.
If you have an allergy to selegiline or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. If you are planning to harm yourself or the want to harm yourself gets worse. A fast heartbeat. Very bad dizziness or passing out. Change in thinking clearly and with logic. Big change in balance. Strong urges that are hard to control (such as gambling or sex). Very nervous and excitable. Very bad flushing. Very bad headache. Very upset stomach or throwing up. Very bad skin irritation. Any rash. Side effect or health problem is not better or you are feeling worse.
Reduce levodopa dosage after initiation
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Antiparkinsonian Drugs , Antidepressants
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