Hydroxy progesterone caproate is a synthetic form of progesterone hormone. Progesterone is normally found in women and is secreted by the ovaries. Hydroxyprogesterone is used in pregnancy to reduce the risk of preterm delivery. The injection is administered to pregnant women who have had a preterm delivery in the past and are currently pregnant.
Hydroxyprogesterone caproate is a synthetic progestin. The exact mechanism of action to reduce the risk of recurrent preterm birth is not known.
The injection is given as a shot into one of your muscles, usually in the hip area. This injection is usually administered once a week.
Some of the possible serious side effects may include
sudden numbness or weakness, especially on one side of the body;
swelling, oozing, bleeding, or worsening pain where the injection was given;
sudden severe headache, confusion, problems with vision, speech, or balance;
pain, swelling, warmth, or redness in one or both legs;
jaundice (yellowing of the skin or eyes);
swelling in your hands, ankles, or feet; or
symptoms of depression (sleep problems, weakness, mood changes).
Less serious side effects may include:
nausea, diarrhea; or
pain, bruising, itching, swelling, or a hard lump where the injection was given
It is vital that you do not miss a dose and you continue to receive the medicine every week. If you miss a dose, call your doctor as soon as you remember for specific advice.
Hydroxyprogesterone should appear as a clear, yellow solution. Do not use hydroxyprogesterone if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
The medicine should not be used in the following conditions
Current thrombosis or thromboembolic disorders or history of these conditions.
Known or suspected breast cancer, other hormone-sensitive cancer, or history of these conditions.
Undiagnosed abnormal vaginal bleeding unrelated to pregnancy.
Cholestatic jaundice of pregnancy.
Liver tumors (benign or malignant) or active liver disease.
It is important that you return to your doctor's office for your weekly shots. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
Stop using this medicine if you have symptoms of pain in the chest, groin, or legs, especially the calves; difficulty with breathing; a sudden, severe headache; slurred speech; a sudden, unexplained shortness of breath; a sudden loss of coordination; or vision changes.
The medicine may also cause serious allergic reactions. Stop using this medicine and check with your doctor if you have a rash, itching, or large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs after you receive the medicine. This medicine may also cause pain, soreness, itching, swelling, or bruising. Consult your doctor if you have increased pain or discomfort, oozing of blood or fluid, or swelling at the injection site.
This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests consult your physician.
Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
Tell your doctor if you ever had any unusual or allergic reaction to this or any other medicines. Also inform him or her if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This medicine is to be administered only by or under the immediate supervision of your doctor. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter (OTC)) medicines and herbal or vitamin supplements.
Hydroxyprogesterone is not intended for use to stop active preterm labor. Discuss any questions or concerns with your doctor.
Diabetes patients - Hydroxyprogesterone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lab tests information required for safe and proper use.
Hydroxyprogesterone should not be used in women who have been through menopause; safety and effectiveness in these patients have not been confirmed.
Hydroxyprogesterone should not be used in children younger than 16 years; safety and effectiveness in these children have not been confirmed.
Tell your doctor if you are taking any other medicines, especially any of the following:
Rifamycins (eg, rifampicin) because they may decrease hydroxyprogesterone's effectiveness
Acetaminophen, bupropion, clozapine, efavirenz, halothane, methadone, nicotine products, theophylline, or tizanidine because their effectiveness may be decreased by hydroxyprogesterone.
The medicine should be stored between 15° and 25°C. The vial should be protected from light and should be stored upright in its box. The medicine should be used within 5 weeks after the first use. Keep it out of the reach of children.
Pregnancy Category: All Trimesters B No adequate or well-controlled studies in women during first trimester
Data from women who received hydroxy progesterone caproate during in their second and third trimesters show no increase in congenital anomalies, including genital abnormalities in male or female infants. If you are or will be breast-feeding while you use hydroxyprogesterone, check with your doctor.
Oestrogens & Progesterones & Related Synthetic Drugs
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