This medication is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would develop into placenta). It is also used in other cancers like blood, breast and lung cancers.
It is also used to suppress immunity in conditions such as psoriasis and rheumatoid arthritis.
It comes as a tablet to take by mouth, with or without food.It also comes as a solution for injection to be administered by a healthcare provide into a large muscle.
Anemia, low white blood cell count, and low platelet count. Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Not hungry. Loose stools (diarrhea). Mouth irritation or sores. Using a soft toothbrush or cotton swabs and rinsing the mouth may help. Do not use mouth rinses that have alcohol in them. Sore throat. Headache. Hair loss. Hair most often grows back when this drug is stopped. Kidney failure may rarely happen. Harm to the liver may rarely happen. Harm to the lungs may rarely happen. Other kinds of cancer may rarely happen later in life.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.
If you have an allergy to methotrexate or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are breast-feeding.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain. Chest pain or pressure. Trouble breathing. Cough that does not go away. Pinpoint red spots on your skin. Very bad belly pain. Very upset stomach or throwing up. Very loose stools (diarrhea). Not able to eat. Any bruising or bleeding. Dark urine or yellow skin or eyes. Feeling very tired or weak. For women, if you get pregnant while taking this drug. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Disease-Modifying Anti-Rheumatic Drugs (DMARDs), Cytotoxic Chemotherapy
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