Topotecan, an alkaloid, is a semi-synthetic derivative of camptothecin which inhibits topoisomerase I, preventing DNA replication and translocation.
Topotecan harms cancer cells causing their death.
Take with or without food. Take with food if it causes an upset stomach. Swallow whole. Do not chew, break, or crush. If you throw up after taking this drug, do not repeat the dose.
Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Anemia, low white blood cell count, and low platelet count. Feeling tired or weak. Headache. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Belly pain. Hard stools (constipation). Loose stools (diarrhea). Hair loss. Hair most often grows back when this drug is stopped. Mouth irritation or sores. Using a soft toothbrush or cotton swabs and rinsing the mouth may help. Do not use mouth rinses that have alcohol in them. Cough. Rash. Harm to the lungs may rarely happen.
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. This drug is taken on an as needed basis.
If you have an allergy to topotecan or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of these health problems: Low white blood cell count, low platelet count, or very bad anemia. If you are pregnant or may be pregnant. If you are breast-feeding.
If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain. Feeling very tired or weak. Trouble breathing. Cough that does not go away. Very bad belly pain. Very upset stomach or throwing up. Very loose stools (diarrhea). Any bruising or bleeding. Dark urine or yellow skin or eyes. Not able to eat. Any rash. Side effect or health problem is not better or you are feeling worse.
Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.
Avoid alcohol. Alcohol, even in small quantities, can worsen the drowsiness caused by Tramadol. It can also affect your reaction time and make it unsafe for you to drive or take part in activities in which you need to be alert.
Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
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